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Research Article| Volume 17, ISSUE 4, P669-683, December 1997

Rapid MB CK Subform Assay and the Early Diagnosis of Myocardial Infarction

  • Robert Roberts
    Correspondence
    Address reprint requests to Robert Roberts, MD, Department of Medicine, Section of Cardiology, 6550 Fannin, MS SM677, Baylor College of Medicine, Houston, TX 77030
    Affiliations
    From the Departments of Medicine and Cell Biology, Section of Cardiology and the Bugher Foundation Center for Molecular Biology, Baylor College of Medicine, Houston, Texas
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30191-4
Rapid MB CK Subform Assay and the Early Diagnosis of Myocardial Infarction
Previous ArticleEvaluation of Cardiac Status CK-MB/Myoglobin Device for Rapidly Ruling Out Acute Myocardial Infarction
Next ArticleChest Pain Centers
      This paper is only available as a PDF. To read, Please Download here.
      To properly triage and treat patients with chest pain, it is necessary to provide an early objective diagnosis of infarction within 4 to 6 hours of onset of symptoms. This need is fueled by the necessity to administer thrombolytic therapy within 6 to 8 hours of onset of infarction, together with the need to be more cost effective in screening patients with chest pain that require admission to the hospital. Results of a large trial performed in 11,000 patients with chest pain showed MB CK Subforms reliably excludes or confirms myocardial infarction in the first 6 hours of onset of symptoms. A more recent multi-centered double blind trial confirmed the sensitivity and specifity of MB CK Subforms for early diagnosis. Furthermore, MB CK Subforms correctly diagnosed all the individuals with MI in the first hour of presentation into the emergency room.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30191-4

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      © 1997 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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