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This article reviews the laboratory methodologies used to evaluate acute lymphoblastic
leukemia (ALL) in children and their role in establishing a diagnosis and prognosis
of this disease. These methodologies are: morphology, flow cytometry, cytogenetics,
and molecular diagnostics. Additionally, immunophenotypic classifications of ALL and
criteria for establishing a diagnosis of ALL independent of morphology are described.
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© 1999 Elsevier Inc. Published by Elsevier Inc. All rights reserved.