Research Article| Volume 19, ISSUE 1, P169-186, March 1999

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Acute Lymphoblastic Leukemia

  • Steven J. Melnick
    Address reprint requests to: Steven J. Melnick, PhD, MD, Department of Pathology, Miami Children’s Hospital, 3100 S.W. 62nd Avenue, Miami, FL 33155.
    From the Department of Pathology and Laboratories, Miami Children’s Hospital, Miami, Florida
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      This paper is only available as a PDF. To read, Please Download here.
      This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics. Additionally, immunophenotypic classifications of ALL and criteria for establishing a diagnosis of ALL independent of morphology are described.
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