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Research Article| Volume 19, ISSUE 1, P87-112, March 1999

Hemolytic Anemia in Children

  • Bertil E. Glader
    Correspondence
    Address reprint requests to: Bertil E. Glader, MD, PhD, Stanford University Medical Center, Pediatric Hematology/Oncology, H–312 300 Pasteur Drive, Stanford, CA 94305–5208.
    Affiliations
    From the Division of Hematology/Oncology, Stanford University School of Medicine, Stanford, California
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      This article provides an overview of hemolytic anemia in children. Main focus areas include acquired immune-mediated hemolysis, hemolytic anemia due to hereditary RBC disorders, hereditary hemolytic disorders caused by enzyme abnormalities, and hereditary hemolytic anemia due to hemoglobin abnormalities.
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      References

        • Beutler E.
        G6PD deficiency.
        Blood. 1994; 84: 3613
        • Beutler E.
        Glucose-6-phosphate dehydrogenase deficiency.
        N Engl J Med. 1991; 324: 169
        • Beutler E.
        The molecular biology of enzymes of erythrocyte metabolism.
        in: Stamatoy-annopoulos G. Nienhus A.W. Majerus P.W. The Molecular Basis of Blood Disease. WB Saunders, Philadelphia1993
        • Beutler E.
        Red Cell Metabolism. A Manual of Biochemical Methods. ed 3. Grune and Stratton, New York1984
        • Brouwers H.A.
        • Overbeeke M.A.
        • van Ertbrugeen I.
        • et al.
        What is the best predictor of the severity of ABO-haemolytic disease of the newborn?.
        Lancet. 1988; 2: 641
        • Embury S.
        Sickle cell disease.
        in: Hoffman R. Benz E. Shatill S. Hematology: Basic Principles and Practice. ed 2. Churchill Livingstone, Edinburgh1995: 611
        • Gallagher P.G.
        • Forget B.G.
        Spectrin genes in health and disease.
        Semin Hematol. 1993; 30: 4
        • Glader B.E.
        Anemia.
        in: Embury S. Hebbel R. Mohandas N. Sickle Cell Disease: Basic Principles and Clinical Practice. Raven Press, New York1994: 545
        • Glader B.E.
        Recognition of anemia and red blood cell disorders during infancy.
        in: Alter B.E. Perinatal Hematology. Methods in Haematology, vol 21. Churchill Livingstone, Edinburgh1989: 126
        • Glader B.E.
        • Look K.
        Hematologic disorders in children from Southeast Asia.
        Pediatr Clin North Am. 1996; X: 665
        • Glader B.E.
        • Lukens J.N.
        Glucose-6-phosphate dehydrogenase deficiency and related disorders of hexose monophosphate shunt and glutathione metabolism.
        in: Lee G.R. Foerster J. Lukens J. Wintrobe’s Clinical Hematology. Williams & Wilkins, Baltimore1998: 1176
        • Glader B.E.
        • Lukens J.N.
        Hereditary hemolytic anemias associated with abnormalities of erythrocyte glycolysis and nucleotide metabolism.
        in: Lee G.R. Foerster J. Lukens J. Wintrobe’s Clinical Hematology. ed 10. Williams & Wilkins, Baltimore1998: 1160
        • Glader B.E.
        • Lukens J.N.
        Hereditary spherocytosis and other hemolytic anemias associated with abnormalities of the red cell membrane and cytoskeleton.
        in: Lee G.R. Foerester J. Lukens J. Wintrobe’s Clinical Hematology. ed 10. Williams & Wilkins, Baltimore1998: 1132
        • Higgs D.R.
        a-Thalassemia.
        in: Higgs D.R. Weatherall D.J. Balliere’s Clinical Hematology. WB Saunders, London1993: 117
        • Hurst D.
        • Tittle B.
        • Kleman K.
        • et al.
        Anemia and hemoglobinopathies in Southeast Asian refugee children.
        J Pediatr. 1983; 102: 692
        • Lorey F.
        • Cunningham G.
        • Shafer F.
        • et al.
        Universal screening for hemoglobinopathies using high-performance liquid chromatography: Clinical results of 2.2 million screens.
        Eur J Hum Genet. 1994; 2: 262
        • Luzzatto L.
        • Mehta A.
        Glucose-6-phosphate dehydrogenase deficiency.
        in: Scriver C. Beaudet A. Sly W. The Metabolic and Molecular Bases of Inherited Disease. ed 7. McGraw-Hill, New York1995
        • Lux S.E.
        • Palek J.
        Disorders of the red cell membrane.
        in: Handin R.I. Lux S.E. Stossel T.O. Blood: Principles and Practice of Hematology. JB Lippincott, Philadelphia1995: 1701
        • Mentzer W.
        • Glader B.E.
        Erythrocyte disorders in infancy.
        in: Taeusch H.W. Ballard R.A. Diseases of the Newborn. ed 7. WB Saunders, Philadelphia1998: 1080
        • Mentzer W.C.
        • et al.
        Modulation of erythrocyte membrane mechanical stability by 2,3-diphosphoglycerate in the neonatal poikilocytosis/elliptocytosis syndrome.
        J Clin Invest. 1987; 79: 943
        • Mentzer Jr, W.C.
        Pyruvate kinase deficiency and disorders of glycolysis.
        in: Nathan D.G. Oski Hematology of Infancy and Childhood, vol 1. ed 4. WB Saunders, Philadelphia1992: 634
        • Paglia D.E.
        Enzymopathies.
        in: Hoffman R. Benz E. Shatill S. Hematology: Basic Principles and Practice. ed 2. Churchill Livingstone, Edinburgh1995: 656
        • Paglia D.E.
        • Valentie W.N.
        Haemolytic anaemia associated with disorders of the purine and pyrimidine salvage pathways.
        Clin Haematol. 1981; 10: 81
        • Paglia D.E.
        • Valentie W.N.
        Red cell nucleotide abnormalities.
        Prog Clin Biol Res. 1984; 165: 213
        • Palek J.
        • Jarolim P.
        Red cell membrane disorders.
        in: Hoffman R. Benz E. Shatill S. Hematology: Basic Principles and Practice. ed 2. Churchill Livingstone, Edinburgh1995: 667
        • Platt O.S.
        • Brambilla D.J.
        • Rosse W.F.
        • et al.
        Mortality in sickle cell disease.
        N Engl J Med. 1994; 330: 23
        • Schneider A.S.
        • et al.
        Hereditary hemolytic anemia with triosephosphate isomerase deficiency.
        N Engl J Med. 1965; 272: 229
        • Schroter W.
        • Kahsnitz E.
        Diagnosis of hereditary spherocytosis in newborn infants.
        J Pediatr. 1983; 103: 460
        • Schwartz E.
        • Benz Jr, E.J.
        • Forget B.G.
        Thalassemia syndromes.
        in: Hoffman R. Benz E. Shatill S. Hematology: Basic Principles and Practice. ed 2. Churchill Livingstone, Edinburgh1995: 586
        • Tanaka K.
        • Paglia D.
        Pyruvate kinase and other enzymopathies of the erythrocyte.
        in: Scriver C. Beaudet A. Sly W. The Metabolic and Molecular Bases of Inherited Disease. ed 7. McGraw-Hill, New York1995
        • Tanaka K.R.
        • et al.
        Red cell enzymopathies of the glycolytic pathway.
        Semin Hematol. 1990; 27: 165
        • Voak D.
        • Williams M.A.
        An explanation of the failure of the direct antiglobulin test to detect erythrocyte sensitization in ABO hemolytic disease of the newborn and observations on pinocytosis of IgG anti-A antibodies by infant (cord) red cells.
        Br J Haematol. 1971; 20: 9
        • Vora S.
        Isozymes of phosphofructokinase.
        in: Rattazzi M.C. Scandalios J.G. Whitt G.S. Isozymes: Current Topics in Biological and Medical Research. Alan R Liss, New York1982