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Over the past decade, a large amount of attention has been directed toward the human papillomavirus (HPV) infection of the genital tract, whereas nongenital infections have been overlooked. These infections are clinically manifested as common warts. In essence, there is a broad spectrum of disease produced at nongenital sites by HPV. Different populations have different susceptibilities and consequences of HPV infection. The purpose of this paper is to review the clinical manifestations of nongenital HPV infection in the immunocompetent and the immunocompromised and those patients with epidermal dysplasia verruciformis. Consideration is given to the differential diagnosis and treatment.
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