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Research Article| Volume 20, ISSUE 2, P383-406, June 2000

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Human Papillomavirus Oncogenesis

  • Ronald C. McGlennen
    Correspondence
    Address reprint requests to: Ronald C. McGlennen, MD, Department of Laboratory Medicine and Pathology, 420 Delaware Street, SE, Box 609, Minneapolis, MN 55455
    Affiliations
    From the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30067-2
Human Papillomavirus Oncogenesis
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      Papillomaviruses are ubiquitous in nature and cause a variety of benign and malignant disease of the skin, respiratory tract, and the genital mucosa. The human papillomavirus (HPV) uniquely has evolved to take advantage of the host cell mechanism of proliferation and differentiation for the purpose of self-replication and the production of infectious virus. The life cycle can be disrupted as a consequence of viral and host cell chromosomes, accompanied by the uncoupling of the normal viral regulation of gene expression. In this setting, 3 viral genes emerge as possessing the ability to cause neoplastic transformation. Most important among these are E6 and E7, which function to disrupt the normal cell cycle checkpoint controls making the host cell susceptible to additional genetic insults.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30067-2

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      © 2000 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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