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Research Article| Volume 20, ISSUE 2, P369-382, June 2000

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Telomerase, Cervical Cancer, and Human Papillomavirus

  • Jan A. Nowak
    Correspondence
    Address reprint requests to: Jan A. Nowak, PhD, MD, Molecular Pathology Laboratory, Illinois Masonic Medical Center, 836 West Wellington Avenue, Chicago, IL 60657
    Affiliations
    From the Molecular Pathology Laboratory, Illinois Masonic Medical Center, Chicago, Illinois
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DOI:https://doi.org/10.1016/S0272-2712(18)30066-0
Telomerase, Cervical Cancer, and Human Papillomavirus
Previous ArticleStatistical Issues in Human Papillomavirus Testing and Screening
Next ArticleHuman Papillomavirus Oncogenesis
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      Telomerase activity is detectable in the majority of cervical squamous cell carcinomas, possibly through interaction with human papillomavirus E6 oncoprotein. Telomerase activity can also be detected in dysplastic epithelium, but the significance of this is obscured by enzyme activity in nondysplastic basal and parabasal cells. The presence of hTR and HTERT expression in many non- neoplastic cells with undetectable or low levels of enzyme activity suggests that telomerase activation is regulated.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30066-0

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      © 2000 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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