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Research Article| Volume 20, ISSUE 2, P345-367, June 2000

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Statistical Issues in Human Papillomavirus Testing and Screening

  • Eduardo L. Franco
    Correspondence
    Address reprint requests to: Eduardo L. Franco, PhD, Division of Epidemiology, Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Québec, Canada H2W 1S6
    Affiliations
    From the Departments of Oncology, Epidemiology and Biostatistics, McGill University, Montreal, Québec, Canada
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30065-9
Statistical Issues in Human Papillomavirus Testing and Screening
Previous ArticleEvaluation of Abnormal Cervical Cytology
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      Much progress has been made in the past 10 years concerning laboratory detection and measurement of human papillomavirus (HPV) infection by amplified and nonamplified DNA hybridization techniques. The advances in laboratory testing for HPV have helped to elucidate the etiologic role that this virus has in cervical carcinogenesis, which has spawned new epidemiologic research on the natural history and prevention of cervical cancer. Regardless of the research purpose, etiology or prevention, there are critical statistical and study design issues related to measurement of HPV infection status and its cervical lesion outcomes that may affect the validity of epidemiologic and screening efficacy studies. Meticulous attention to study conduct and laboratory detection helps to minimize the influence of measurement errors and detection biases. Simple statistical analysis techniques are also available to correct or to control for some of the problems.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30065-9

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      © 2000 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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