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Research Article| Volume 20, ISSUE 2, P257-270, June 2000

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Human Papillomavirus in Cervical Neoplasia: Role, Risk Factors, and Implications

  • C. Meg McLachlin
    Correspondence
    Address reprint requests to: C. Meg McLachlin, MD, FRCPC, Departments of Pathology and Obstetrics and Gynecology, London Health Sciences Centre, University of Western Ontario, 375 South Street, London, Ontario, Canada N6A 4G5
    Affiliations
    From the Departments of Pathology and Obstetrics and Gynecology, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30061-1
Human Papillomavirus in Cervical Neoplasia: Role, Risk Factors, and Implications
Previous ArticleHuman Papillomavirus: Epidemiology, Transmission, and Pathogenesis
Next ArticleDiagnosis of Human Papillomavirus Gynecologic Infections
      This paper is only available as a PDF. To read, Please Download here.
      A rapidly increasing body of evidence links human papillomavirus (HPV) to cervical neoplasia through epidemiologic associations, pathologic features, molecular detection, and mechanisms of oncogenesis. HPV is now accepted as the primary cause of cervical neoplasia and accounts for most of the risk factors traditionally associated with this disease. The role that HPV plays in the induction and progression of cervical neoplasia is becoming clearer; however, the challenge now is to find other factors that may play a role in the outcome of cervical cancer and that might serve as targets for novel treatments.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30061-1

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      © 2000 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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