Research Article| Volume 20, ISSUE 3, P623-638, September 2000

Anabolic Therapies

  • Robert Marcus
    Address reprint requests to Robert Marcus, MD, Geriatrics Research, Education, and Clinical Center, VA Palo Alto Health Care System, GREEC 182-B, 3801 Miranda Avenue, Palo Alto, CA 94304.
    From the Geriatrics Research, Education, and Clinical Center, VA Palo Alto Health Care System; and the Department of Medicine, Stanford University School of Medicine, Palo Alto, California
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      The possibility of anabolic therapy continues to excite the bone research community. Substantial clinical benefit may accrue with parathyroid hormone if preliminary evidence concerning antifracture efficacy is confirmed. Human growth hormone shows little or no promise as an anabolic agent for bone. Fluoride achieves substantial increases in bone mineral density, but its ability to prevent fractures remains highly contentious. It seems likely that, along with the possible addition of parathyroid hormone to the therapeutic armamentarium, preventive measures and potent antiresorptive drugs will remain the mainstay of osteoporosis therapy for the next several years.
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