Research Article| Volume 20, ISSUE 3, P489-502, September 2000

Biochemical Markers of Bone Formation

  • Caren M. Gundberg
    Address reprint requests to Caren M. Gundberg, PhD, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510.
    From the Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut
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      The biochemical markers of bone formation are comprised of products of osteoblastic synthesis. These include N- and C-propeptides of type I collagen, osteocalcin, and bone-specific alkaline phosphatase. This article reviews the biochemistry and physiology of these markers. The various methods currently available for their determination are evaluated. Finally, the clinical use of these markers in the management of osteoporosis is discussed.
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