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Research Article| Volume 20, ISSUE 3, P455-468, September 2000

Pathophysiology of Osteoporosis

  • Clifford J. Rosen
    Correspondence
    Address reprint requests to Clifford J. Rosen, MD, Maine Center for Osteoporosis, Research and Education, St. Joseph Hospital, Bangor, ME 04401.
    Affiliations
    From the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30047-7
Pathophysiology of Osteoporosis
Previous ArticleEpidemiology of Fractures and Assessment of Fracture Risk
Next ArticleBone Densitometry
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      Osteoporosis is associated with a reduction in bone mass and a significant alteration in bone architecture. These changes lead to enhanced skeletal fragility. Impairment in peak bone acquisition and rapid bone loss result in low bone mineral density and a greater risk of fractures. Genetic, environmental, hormonal, and nutritional factors are major determinants of bone mass and are important in understanding the pathophysiology of osteoporosis.
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      Article info

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30047-7

      Copyright

      © 2000 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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