Research Article| Volume 20, ISSUE 3, P455-468, September 2000

Pathophysiology of Osteoporosis

  • Clifford J. Rosen
    Address reprint requests to Clifford J. Rosen, MD, Maine Center for Osteoporosis, Research and Education, St. Joseph Hospital, Bangor, ME 04401.
    From the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.
      Osteoporosis is associated with a reduction in bone mass and a significant alteration in bone architecture. These changes lead to enhanced skeletal fragility. Impairment in peak bone acquisition and rapid bone loss result in low bone mineral density and a greater risk of fractures. Genetic, environmental, hormonal, and nutritional factors are major determinants of bone mass and are important in understanding the pathophysiology of osteoporosis.
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