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Research Article| Volume 21, ISSUE 3, P631-660, September 2001

Applying Molecular Biological Techniques to Detecting Biological Agents

  • Amy E. Krafft
    Correspondence
    Address reprint requests to Amy E. Krafft, PhD, Molecular Diagnostics Laboratory, Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue NW, Washington, DC 20036.
    Affiliations
    From the Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC
    Search for articles by this author
  • David A. Kulesh
    Affiliations
    Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
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DOI:https://doi.org/10.1016/S0272-2712(18)30026-X
Applying Molecular Biological Techniques to Detecting Biological Agents
Previous ArticleThe Emerging Impact of Genomics on the Development of Biological Weapons: Threats and Benefits Posed by Engineered Extremophiles
Next ArticleCurrent Laboratory Methods for Biological Threat Agent Identification
      This paper is only available as a PDF. To read, Please Download here.
      Recent innovations in nucleic acid probe chemistry and amplification technology have made possible new automated laboratory systems for rapid detection of infectious agents. An overview of new fluorescent probe and real-time amplification technologies useful for detection of unusual bacterial and exotic viral agents seldom seen in patients with the potential for use in acts of bioterrorism is presented. Available genomic information and unique gene targets for molecular detection of many potential bioagents that cannot be cultured readily by routine microbiologic methods are also provided.
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