Review Article| Volume 35, ISSUE 3, P567-577, September 2015

Use of Lactate in Small Animal Clinical Practice


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        • Pang D.S.
        • Boysen S.
        Lactate in veterinary critical care: pathophysiology and management.
        J Am Anim Hosp Assoc. 2007; 43: 270-279
        • Shapiro B.A.
        • Peruzzi W.T.
        Interpretation of blood gases.
        in: Ayres S.M. Grenvik A. Holbrook P.R. Textbook of critical care. 3rd edition. WB Saunders, Philadelphia1995: 278-294
        • Tonnessen T.I.
        Intracellular pH and electrolyte regulation.
        in: Ayres S.M. Grenvik A. Holbrook P.R. Textbook of critical care. 3rd edition. WB Saunders, Philadelphia1995: 172-187
        • Allen S.E.
        • Holm J.L.
        Lactate: physiology and clinical utility.
        J Vet Emerg Crit Care. 2008; 18: 123-132
        • Hughes D.
        • Rozanski E.R.
        • Shofer F.S.
        • et al.
        Effect of sampling site, repeated sampling, pH, and PCO2 on plasma lactate concentrations in healthy dogs.
        Am J Vet Res. 1999; 60: 521-524
        • McMichael M.A.
        • Lees G.E.
        • Hennessey J.
        • et al.
        Serial plasma lactate concentrations in 68 puppies aged 4 to 80 days.
        J Vet Emerg Crit Care. 2005; 15: 17-21
        • Packer R.A.
        • Cohn L.A.
        • Wohlstadter D.R.
        • et al.
        d-Lactic acidosis secondary to exocrine pancreatic insufficiency in a cat.
        J Vet Intern Med. 2005; 19: 106-110
        • Vernon C.
        • LeTourneau J.L.
        Lactic acidosis: recognition, kinetics, and associated prognosis.
        Crit Care Clin. 2010; 26: 255-283
        • dePapp E.
        • Drobatz K.J.
        • Hughes D.
        Plasma lactate concentration as a predictor of gastric necrosis and survival among dogs with gastric dilatation-volvulus: 102 cases (1995–1998).
        J Am Vet Med Assoc. 1999; 215: 49-52
        • Lagutchik M.S.
        • Ogilvie G.K.
        • Hackett T.B.
        • et al.
        Increased lactate concentrations in ill and injured dogs.
        J Vet Emerg Crit Care. 1998; 8: 117-127
        • Nel M.
        • Lobetti R.G.
        • Keller N.
        • et al.
        Prognostic value of blood lactate, blood glucose, and hematocrit in canine babesiosis.
        J Vet Intern Med. 2004; 18: 471-476
        • Mathews K.A.
        Monitoring fluid therapy and complications of fluid therapy.
        in: DiBartola S.P. Fluid, electrolyte, and acid-base disorders in small animal practice. 4th edition. Elsevier Saunders, St Louis (MO)2012: 386-404
        • Madias N.E.
        Lactic acidosis.
        Kidney Int. 1986; 29: 752-774
        • Yudkin J.
        • Cohen R.D.
        The contribution of the kidney to the removal of a lactic acid load under normal and acidotic conditions in the conscious rat.
        Clin Sci Mol Med. 1975; 48: 121-131
        • Record C.O.
        • Iles R.A.
        • Cohen R.D.
        • et al.
        Acid-base and metabolic disturbances in fulminant hepatic failure.
        Gut. 1975; 16: 144-149
        • Claus M.A.
        • Jandrey K.E.
        • Poppenga R.H.
        Propylene glycol intoxication in a dog.
        J Vet Emerg Crit Care. 2011; 21: 679-683
        • Packer R.A.
        • Moore G.E.
        • Chang C.Y.
        • et al.
        Serum d-lactate concentrations in cats with gastrointestinal disease.
        J Vet Intern Med. 2012; 26: 905-910
        • Kruse J.A.
        • Carlson R.W.
        Lactate metabolism.
        Crit Care Clin. 1987; 5: 725-746
        • Luft F.C.
        Lactic acidosis update for critical care clinicians.
        J Am Soc Nephrol. 2001; 12: S15-S19
        • Mizock B.A.
        • Falk J.L.
        Lactic acidosis in critical illness.
        Crit Care Med. 1992; 20: 80-93
        • Stryer L.
        Oxidative phosphorylation.
        in: Stryer L. Biochemistry. 4th edition. WH Freeman and Company, New York1995: 529-558
        • Lagutchik M.S.
        in: Vade S.L. Knoll J.S. Smith F.W. Blackwell’s five-minute veterinary consult: laboratory tests and diagnostic procedures. Wiley-Blackwell Publishing, Ames (IA)2009: 388-389
        • Karon B.S.
        • Scott R.
        • Burritt M.F.
        • et al.
        Comparison of lactate values between point-of care and central laboratory analyzers.
        Am J Clin Pathol. 2007; 128: 168-171
        • Rand J.S.
        • Kinnaird E.
        • Baglioni A.
        • et al.
        Acute stress hyperglycemia in cats is associated with struggling and increased concentrations of lactate and norepinephrine.
        J Vet Intern Med. 2002; 16: 123-132
        • Redavid L.A.
        • Sharp C.R.
        • Mitchell M.A.
        • et al.
        Plasma lactate measurement in healthy cats.
        J Vet Emerg Crit Care. 2012; 22: 580-587
        • Karagiannis M.H.
        • Mann F.A.
        • Madsen R.W.
        • et al.
        Comparison of two portable lactate meters in dogs.
        J Am Anim Hosp Assoc. 2013; 49: 8-15
        • Thorneloe C.
        • Bedard C.
        • Boysen S.
        Evaluation of a hand held lactate analyzer in dogs.
        Can Vet J. 2007; 48: 283-287
        • Hopper K.
        Falsely increased plasma lactate concentration due to ethylene glycol poisoning in 2 dogs.
        J Vet Emerg Crit Care. 2013; 23: 63-67
        • Didwania A.
        • Miller J.
        • Kassel D.
        • et al.
        Effect of intravenous lactated ringer’s solution infusion on the circulating lactate concentration: part 3. Results of a prospective, randomized, double-blind, placebo-controlled trial.
        Crit Care Med. 1997; 25: 1851-1854
        • Pascoe P.J.
        Perioperative management of fluid therapy.
        in: DiBartola S.P. Fluid, electrolyte, and acid-base disorders in small animal practice. 3rd edition. Elsevier, St Louis (MO)2006: 391-419
        • Us M.H.
        • Ozcan S.
        • Oral L.
        • et al.
        Comparison of the effects of hypertonic saline and crystalloid infusions on haemodynamic parameters during haemorrhagic shock in dogs.
        J Int Med Res. 2001; 29: 508-515
        • Vail D.M.
        • Ogilvie G.K.
        • Fettman M.J.
        • et al.
        Exacerbation of hyperlactemia by infusion of lactated ringer’s solution in dogs with lymphoma.
        J Vet Intern Med. 1990; 4: 228-232
        • Touret M.
        • Boysen S.R.
        • Nadeau M.E.
        Retrospective evaluation of potential causes associated with clinically relevant hyperlactatemia in dogs with lymphoma.
        Can Vet J. 2012; 53: 511-517
        • Jackson E.V.
        • Wiese J.
        • Sigal B.
        • et al.
        Effects of crystalloid solutions on circulating lactate concentrations: part I. Implications for the proper handling of blood specimens obtained from critically ill patients.
        Crit Care Med. 1997; 25: 1840-1846
        • Hopper K.
        • Epstein S.E.
        Incidence, nature, and etiology of metabolic acidosis in dogs and cats.
        J Vet Intern Med. 2012; 26: 1107-1114
        • Stevenson C.K.
        • Kidney B.A.
        • Duke T.
        • et al.
        Serial blood lactate concentrations in systemically ill dogs.
        Vet Clin Pathol. 2007; 36: 234-239
        • Vitek V.
        • Cowle R.A.
        Blood lactate in the prognosis of various forms of shock.
        Ann Surg. 1971; 173: 308-313
        • Hicks C.W.
        • Sweeney D.A.
        • Danner R.L.
        • et al.
        Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock.
        Crit Care Med. 2012; 40: 199-207
        • Hagman R.
        • Reezigt B.J.
        • Ledin H.B.
        • et al.
        Blood lactate levels in 31 female dogs with pyometra.
        Acta Vet Scand. 2009; 51: 2-9
        • Green T.I.
        • Tonozzi C.C.
        • Kirby R.
        • et al.
        Evaluation of initial plasma lactate values as a predictor of gastric necrosis and initial and subsequent plasma lactate values as a predictor of survival in dogs with gastric dilatation-volvulus: 84 dogs (2003-2007).
        J Vet Emerg Crit Care. 2011; 21: 36-44
        • Zacher L.A.
        • Berg J.
        • Shaw S.P.
        • et al.
        Association between outcome and changes in plasma lactate concentration during presurgical treatment in dogs with gastric dilatation-volvulus; 64 cases.
        J Am Vet Med Assoc. 2010; 236: 892-897
        • Beer K.A.
        • Syring R.S.
        • Drobatz K.J.
        Evaluation of plasma lactate concentration and base excess at the time of hospital admission as predictors of gastric necrosis and outcome and correlation between those variables in dogs with gastric dilatation-volvulus: 78 cases (2004-2009).
        J Am Vet Med Assoc. 2013; 242: 54-58
        • Holahan M.L.
        • Brown A.J.
        • Drobatz K.J.
        The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases.
        J Vet Emerg Crit Care. 2010; 20: 413-420
        • Ferasin L.
        • Marcora S.
        Reliability of an incremental exercise test to evaluate acute blood lactate, heart rate, and body temperature responses in Labrador Retrievers.
        J Comp Physiol B. 2009; 179: 839-845
        • Baltzer W.I.
        • Firshman A.M.
        • Stang B.
        • et al.
        The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs.
        BMC Vet Res. 2012; 8: 249-259
        • Christopher M.M.
        • O’Neill S.
        Effect of specimen collection and storage on blood glucose and lactate concentrations in healthy, hyperthyroid and diabetic cats.
        Vet Clin Pathol. 2000; 29: 22-28
        • Sullivan L.A.
        • Campbell V.L.
        • Klopp L.S.
        • et al.
        Blood lactate concentrations in anesthetized dogs with intracranial disease.
        J Vet Intern Med. 2009; 23: 488-492
        • Touret M.
        • Boysen S.R.
        • Nadeau M.E.
        Prospective evaluation of clinically relevant type B hyperlactatemia in dogs with cancer.
        J Vet Intern Med. 2010; 24: 1458-1461
        • Boysen S.R.
        • Bozzetti M.
        • Rose L.
        • et al.
        Effects of prednisone on blood lactate concentrations in healthy dogs.
        J Vet Intern Med. 2009; 23: 1123-1125
        • Shelton G.D.
        Routine and specialized laboratory testing for the diagnosis of neuromuscular diseases in dogs and cats.
        Vet Clin Pathol. 2010; 39: 278-295
        • Abramson C.J.
        • Platt S.R.
        • Shelton G.D.
        Pyruvate dehydrogenase deficiency in a Sussex spaniel.
        J Small Anim Pract. 2004; 45: 162-165
        • Bonczynski J.J.
        • Ludwig L.L.
        • Tarton L.F.
        • et al.
        Comparison of peritoneal fluid and peripheral blood pH, bicarbonate, glucose and lactate concentrations a diagnostic tool for septic peritonitis in dogs and cats.
        Vet Surg. 2003; 32: 161-166
        • Levin G.M.
        • Bonczynski J.J.
        • Ludwig L.L.
        • et al.
        Lactate as a diagnostic test for septic peritoneal effusions in dogs and cats.
        J Am Anim Hosp Assoc. 2004; 40: 364-371
      1. Swann H, Hughes D. Use of abdominal fluid pH, pO2, [glucose], and [lactate] to differentiate bacterial peritonitis from non-bacterial causes of abdominal effusion in dogs and cats. Proceed International Veterinary Emergency and Critical Care Society Meeting. San Antonio (TX): 1996. p. 884.

        • Nestor D.D.
        • McCullough S.M.
        • Schaeffer D.J.
        Biochemical analysis of neoplastic versus nonneoplastic abdominal effusions in dogs.
        J Am Anim Hosp Assoc. 2004; 40: 372-375
        • de Laforcade A.M.
        • Freeman L.M.
        • Rozanski E.A.
        • et al.
        Biochemical analysis of pericardial fluid and whole blood in dogs with pericardial effusion.
        J Vet Intern Med. 2005; 19: 833-836