Advertisement
Review Article| Volume 34, ISSUE 3, P675-686, September 2014

The Influence of Various Patient Characteristics on D-dimer Concentration in Critically Ill Patients and Its Role as a Prognostic Indicator in the Intensive Care Unit Setting

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Gaffney P.J.
        • Lane D.A.
        • Kakkar V.V.
        • et al.
        Characterisation of a soluble D dimer-E complex in crosslinked fibrin digests.
        Thromb Res. 1975; 7: 89-99
        • Adam S.S.
        • Key N.S.
        • Greenberg C.S.
        D-dimer antigen: current concepts and future prospects.
        Blood. 2009; 113: 2878-2887
        • Gaffney P.J.
        • Joe F.
        The lysis of crosslinked human fibrin by plasmin yields initially a single molecular complex, D dimer-E.
        Thromb Res. 1979; 15: 673-687
        • Bates S.M.
        D-dimer assays in diagnosis and management of thrombotic and bleeding disorders.
        Semin Thromb Hemost. 2012; 38: 673-682
        • Walker J.B.
        • Nesheim M.E.
        The molecular weights, mass distribution, chain composition, and structure of soluble fibrin degradation products released from a fibrin clot perfused with plasmin.
        J Biol Chem. 1999; 274: 5201-5212
        • Di Nisio M.
        • Squizzato A.
        • Rutjes A.W.
        • et al.
        Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review.
        J Thromb Haemost. 2007; 5: 296-304
        • Levi M.
        Disseminated intravascular coagulation.
        Crit Care Med. 2007; 35: 2191-2195
        • Taylor Jr., F.B.
        • Toh C.H.
        • Hoots W.K.
        • et al.
        Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.
        Thromb Haemost. 2001; 86: 1327-1330
        • Lee J.H.
        • Song J.W.
        • Song K.S.
        Diagnosis of overt disseminated intravascular coagulation: a comparative study using criteria from the International Society versus the Korean Society on Thrombosis and Hemostasis.
        Yonsei Med J. 2007; 48: 595-600
        • Karami-Djurabi R.
        • Klok F.A.
        • Kooiman J.
        • et al.
        D-dimer testing in patients with suspected pulmonary embolism and impaired renal function.
        Am J Med. 2009; 122: 1050-1053
        • Qasim A.
        • Duggan M.
        • O'Connell N.
        • et al.
        Clinical conditions and patient factors significantly influence diagnostic utility of D-dimer in venous thromboembolism.
        Blood Coagul Fibrinolysis. 2009; 20: 244-247
        • Legnani C.
        • Cini M.
        • Cosmi B.
        • et al.
        Age and gender specific cut-off values to improve the performance of D-dimer assays to predict the risk of venous thromboembolism recurrence.
        Intern Emerg Med. 2013; 8: 229-236
        • Gordge M.P.
        • Faint R.W.
        • Rylance P.B.
        • et al.
        Plasma D dimer: a useful marker of fibrin breakdown in renal failure.
        Thromb Haemost. 1989; 61: 522-525
        • Pieper C.F.
        • Rao K.M.
        • Currie M.S.
        • et al.
        Age, functional status, and racial differences in plasma D-dimer levels in community-dwelling elderly persons.
        J Gerontol A Biol Sci Med Sci. 2000; 55: M649-M657
        • Lee A.J.
        • Fowkes G.R.
        • Lowe G.D.
        • et al.
        Determinants of fibrin D-dimer in the Edinburgh Artery Study.
        Arterioscler Thromb Vasc Biol. 1995; 15: 1094-1097
        • Shlipak M.G.
        • Fried L.F.
        • Crump C.
        • et al.
        Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency.
        Circulation. 2003; 107: 87-92
        • Kabrhel C.
        • Mark Courtney D.
        • Camargo Jr., C.A.
        • et al.
        Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism.
        Acad Emerg Med. 2010; 17: 589-597
        • Catena C.
        • Zingaro L.
        • Casaccio D.
        • et al.
        Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance.
        Am J Med. 2000; 109: 556-561
        • Penaloza A.
        • Roy P.M.
        • Kline J.
        • et al.
        Performance of age-adjusted D-dimer cut-off to rule out pulmonary embolism.
        J Thromb Haemost. 2012; 10: 1291-1296
        • Douma R.A.
        • le Gal G.
        • Sohne M.
        • et al.
        Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts.
        BMJ. 2010; 340: c1475
        • Siragusa S.
        Plasma D-dimer test accuracy can be affected by heparin administration.
        Arch Intern Med. 2003; 163 ([author reply: 247]): 246
        • Hoste E.A.
        • Kellum J.A.
        Acute kidney injury: epidemiology and diagnostic criteria.
        Curr Opin Crit Care. 2006; 12: 531-537
        • Elseviers M.M.
        • Lins R.L.
        • Van der Niepen P.
        • et al.
        Renal replacement therapy is an independent risk factor for mortality in critically ill patients with acute kidney injury.
        Crit Care. 2010; 14: R221
        • Thompson S.
        • Pannu N.
        Dialysis patients and critical illness.
        Am J Kidney Dis. 2012; 59: 145-151
        • Ay C.
        • Dunkler D.
        • Pirker R.
        • et al.
        High D-dimer levels are associated with poor prognosis in cancer patients.
        Haematologica. 2012; 97: 1158-1164
        • Nagy Z.
        • Horvath O.
        • Kadas J.
        • et al.
        D-dimer as a potential prognostic marker.
        Pathol Oncol Res. 2012; 18: 669-674
        • Stender M.T.
        • Larsen T.B.
        • Sorensen H.T.
        • et al.
        Preoperative plasma D-dimer predicts 1-year survival in colorectal cancer patients with absence of venous thromboembolism (VTE): a prospective clinical cohort study.
        J Thromb Haemost. 2012; 10: 2027-2031
        • Raj S.D.
        • Zhou X.
        • Bueso-Ramos C.E.
        • et al.
        Prognostic significance of elevated D-dimer for survival in patients with sarcoma.
        Am J Clin Oncol. 2012; 35: 462-467
        • Ohlmann P.
        • Faure A.
        • Morel O.
        • et al.
        Diagnostic and prognostic value of circulating D-dimers in patients with acute aortic dissection.
        Crit Care Med. 2006; 34: 1358-1364
        • Weber T.
        • Rammer M.
        • Auer J.
        • et al.
        Plasma concentrations of D-dimer predict mortality in acute type A aortic dissection.
        Heart. 2006; 92: 836-837
        • Stein P.D.
        • Janjua M.
        • Matta F.
        • et al.
        Prognostic value of D-dimer in stable patients with pulmonary embolism.
        Clin Appl Thromb Hemost. 2011; 17: E183-E185
        • Aujesky D.
        • Roy P.M.
        • Guy M.
        • et al.
        Prognostic value of D-dimer in patients with pulmonary embolism.
        Thromb Haemost. 2006; 96: 478-482
        • Ghanima W.
        • Abdelnoor M.
        • Holmen L.O.
        • et al.
        D-dimer level is associated with the extent of pulmonary embolism.
        Thromb Res. 2007; 120: 281-288
        • Shitrit D.
        • Izbicki G.
        • Shitrit A.B.
        • et al.
        Prognostic value of a new quantitative D-dimer test in critically ill patients 24 and 48 h following admission to the intensive care unit.
        Blood Coagul Fibrinolysis. 2004; 15: 15-19
        • Shorr A.F.
        • Trotta R.F.
        • Alkins S.A.
        • et al.
        D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease.
        Intensive Care Med. 1999; 25: 207-210
        • Kollef M.H.
        • Eisenberg P.R.
        • Shannon W.
        A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients.
        Crit Care Med. 1998; 26: 1054-1060
        • Levey A.S.
        • Stevens L.A.
        • Schmid C.H.
        • et al.
        A new equation to estimate glomerular filtration rate.
        Ann Intern Med. 2009; 150: 604-612
        • Matsushita K.
        • Mahmoodi B.K.
        • Woodward M.
        • et al.
        Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate.
        JAMA. 2012; 307: 1941-1951
        • Matsushita K.
        • Tonelli M.
        • Lloyd A.
        • et al.
        Clinical risk implications of the CKD Epidemiology Collaboration (CKD-EPI) equation compared with the Modification of Diet in Renal Disease (MDRD) Study equation for estimated GFR.
        Am J Kidney Dis. 2012; 60: 241-249
        • National Kidney Foundation
        KDOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.
        Am J Kidney Dis. 2002; 39: S1-S266
        • Dubin R.
        • Cushman M.
        • Folsom A.R.
        • et al.
        Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis.
        BMC Nephrol. 2011; 12: 3
        • Ambuhl P.M.
        • Wuthrich R.P.
        • Korte W.
        • et al.
        Plasma hypercoagulability in haemodialysis patients: impact of dialysis and anticoagulation.
        Nephrol Dial Transplant. 1997; 12: 2355-2364
        • Kollef M.H.
        • Zahid M.
        • Eisenberg P.R.
        Predictive value of a rapid semiquantitative D-dimer assay in critically ill patients with suspected venous thromboembolic disease.
        Crit Care Med. 2000; 28: 414-420
        • Goldhaber S.Z.
        The perils of D-dimer in the medical intensive care unit.
        Crit Care Med. 2000; 28: 583-584