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Disclosure: M.M. Samama has received research grants, consulting fees as a member of advisory boards, and speaker and/or investigator fees from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb (BMS), Daichii Sankyo, GlaxoSmithKline (GSK), Pfizer, Rovi, and Sanofi. S. Meddahi discloses no conflict of interest. C.M. Samama has received research grants, consulting fees as a member of advisory boards, and speaker and/or investigator fees from Abbott, AstraZeneca, Baxter, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb (BMS), CSL Behring, Daiichi Sankyo, Fresenius-Kabi, GlaxoSmithKline (GSK), Haemonetics, Laboratoire Français du Fractionnement et des Biotechnologies (LFB), Lilly, Novo Nordisk, Pfizer, Rovi, and Sanofi.