Review Article| Volume 34, ISSUE 1, P31-41, March 2014

Cardiac Markers of Myocardial Necrosis

A History and Discussion of Milestones and Emerging New Trends
Published:January 16, 2014DOI:


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        • Ladenson J.
        A personal history of markers of myocyte injury (myocardial infarction).
        Clin Chim Acta. 2007; 381: 3-8
        • Ladenson J.
        Reflections on the evolution of cardiac biomarkers.
        Clin Chem. 2012; 58: 21-24
        • Dolci A.
        • Panteghini M.
        The exciting story of cardiac biomarkers: from retrospective detection to gold standard for acute myocardial infarction and more.
        Clin Chim Acta. 2006; 369: 179-187
        • Kelley W.
        • Januzzi J.
        • Christenson R.
        Increases in cardiac troponin in conditions other than acute coronary syndrome and heart failure.
        Clin Chem. 2009; 55: 2098-2112
        • Thygesen K.
        • Alpert J.S.
        • Jaffe A.S.
        • et al.
        Third universal definition of myocardial infarction.
        Circulation. 2012; 126: 2020-2035
        • Gibler B.
        • Gibler C.
        • Weinshenker E.
        • et al.
        Myoglobin as an early indicator of acute myocardial infarction.
        Ann Emerg Med. 1987; 16: 851-856
        • Gibler B.
        • Lewis L.
        • Erb R.
        • et al.
        Early detection of acute myocardial infarction in patients presenting with chest pain and nondiagnostic ECGs: serial CK-MB sampling in the emergency department.
        Ann Emerg Med. 1990; 19: 1359-1366
        • McCord J.
        • Nowak R.
        • McCullough P.
        • et al.
        Ninety minute exclusion of acute myocardial infarction by the use of quantitative point-of-care testing of myoglobin and troponin I.
        Circulation. 2001; 104: 1483-1488
        • Ming S.
        • Krishnaswamy P.
        • Morissey R.
        • et al.
        Ninety minute accelerated critical pathway for chest pain.
        Am J Cardiol. 2001; 88: 611-617
        • Storrow A.
        • Lindsell C.
        • Collins S.
        • et al.
        Emergency department multimarker point-of-care testing reduces time to cardiac marker results without loss of diagnostic accuracy.
        Point Care. 2006; 5: 132-136
        • Dadkhah S.
        • Sharain K.
        • Sharain R.
        • et al.
        The value of bedside cardiac biomarker assay in rapid and accurate diagnosis of acute coronary syndromes.
        Crit Pathw Cardiol. 2007; 6: 76-84
        • Storrow A.
        • Lyon J.
        • Porter M.
        • et al.
        A systematic review of emergency department point-of-care cardiac markers and efficiency measures.
        Point Care. 2009; 8: 121-125
        • Lee-Lewandrowski E.
        • Januzzi J.
        • Grisson R.
        • et al.
        Evaluation of first-draw whole blood, point-of-care cardiac markers in the context of the universal definition of myocardial infarction: a comparison of a multimarker panel to troponin alone and to testing in the central laboratory.
        Arch Pathol Lab Med. 2011; 135: 459-463
        • Tate J.
        • Christenson R.
        • Katrukha A.
        Standardization of cardiac troponin I measurement: past and present.
        Pathology. 2010; 42: 402-408
        • Wu A.
        • Lane P.
        Meta-analysis in clinical chemistry: validation of cardiac troponin T as a marker for ischemic heart disease.
        Clin Chem. 1995; 41: 1228-1233
        • Ottani F.
        • Galvani M.
        • Nicolini F.
        • et al.
        Elevated cardiac troponin levels predict the risk of adverse outcomes in patients with acute coronary syndromes.
        Am Heart J. 2000; 140: 917-927
        • Saenger A.
        • Jaffe A.
        Requiem for a heavyweight: the demise of creatine kinase-MB.
        Circulation. 2008; 118: 2200-2206
        • Apple F.
        A new season for cardiac troponin assays: its time to keep a scorecard.
        Clin Chem. 2009; 55: 1303-1306
        • Korley F.
        • Jaffe A.
        Preparing the United States for high-sensitivity cardiac troponin assays.
        J Am Coll Cardiol. 2013; 61: 1753-1758
        • Reichlin T.
        • Hochholzer W.
        • Bassetti S.
        • et al.
        Early diagnosis of myocardial infarction with sensitive cardiac troponin assays.
        N Engl J Med. 2009; 361: 858-867
        • Hammarsten O.
        • Fu M.
        • Sigurjonsdottir R.
        • et al.
        Troponin T percentiles from a random population sample, emergency room patients and patients with myocardial infarction.
        Clin Chem. 2012; 58: 628-637