The Bible recounts the tumultuous story of the patriarch Jacob during his sojourn in the House of Laban in his quest to betroth the matriarch Rachel. Despite Laban’s continuous trickery, deception, and debauchery in an effort to prohibit Jacob from claiming his due, whether in his marriage to Rachel or his earning of agreed upon wages, Jacob somewhat successfully prevails. Jacob, being attuned to Laban’s malfeasance, proposes an odd request for wages. A rather obscure passage states the following: “Let me go through all your flocks today and remove from them every speckled or spotted sheep, every dark colored lamb and every spotted or speckled goat. They will be my wages.”
Although many commentaries postulate this episode as an intended exercise using classical genetics, selective breeding, physiology, and epigenetics,
4as well as in humans. Indeed, molecular medicine with respect to heredity probabilities, polymorphisms, recombination genetics, pharmacogenomics, pharmacogenetics, and the like in malignancy and other disease spaces has gained considerable popularity over the last decade with the current culmination of personalized medicine.
- Hall I.M.
- Quinlan A.R.
Detection and interpretation of genomic structural variation in mammals.
Methods Mol Biol. 2012; 838: 225-248
- Mendelsohn J.
Personalizing oncology: perspectives and prospects.
J Clin Oncol. 2013; 31: 1904-1911
6Whereas years ago one would subscribe to the mantra “one gene one protein” hypothesis, today’s medical marketplace is seeing a paradigm shift in assessing multiplex interplays of factors that demonstrate pathway effects, which are taken into account in disease diagnosis, prognosis, therapeutic intervention, and patient management strategies.
- Johnson J.A.
- Cavallari L.H.
Pharmacogenetics and cardiovascular disease—implications for personalized medicine.
Pharmacol Rev. 2013; 65: 987-1009
- Starčević J.N.
- Petrovič D.
Carotid intima media-thickness and genes involved in lipid metabolism in diabetic patients using statins—a pathway toward personalized medicine.
Cardiovasc Hematol Agents Med Chem. 2013; 11: 3-8
Molecular pathology, the discipline within pathology that focuses on the study and diagnosis of disease through the examination of molecules within organs, tissues, or bodily fluids,
The diagnostic methodological armamentarium has expanded considerably to include interrogation of nucleic acid—encompassing polymerase chain reaction (PCR) and its permutations (ie, real-time PCR), FISH, SNPs, and miRNA, among others—as well as protein assessment (ie, ELISA, Western Blot, IHC). Furthermore, the “omics” explosion, presenting a unique manner of high throughput technologies, will also further expound on disease from a biological systems approach.
9In addition, cellular and tissue microarrays
- Chen R.
- Snyder M.
Promise of personalized omics to precision medicine.
Wiley Interdiscip Rev Syst Biol Med. 2013; 5: 73-82
- Papp K.
- Szittner Z.
- Prechl J.
Life on a microarray: assessing live cell functions in a microarray format.
Cell Mol Life Sci. 2012; 69: 2717-2725
11hold additional promise for biomarker discovery, development, maturation, and application to various diseases.
- Franco R.
- Caraglia M.
- Facchini G.
- et al.
The role of tissue microarray in the era of target-based agents.
Expert Rev Anticancer Ther. 2011; 11: 859-869
To this end, the molecular pathologist may be likened to a modern day “molecular shepherd,” who will facilitate the evolution of the personalized medicine era and translate such into cogent, meaningful laboratory data toward the application to disease diagnosis, prognosis, and patient management for the betterment of mankind.
Available at: http://www.volconvo.com/forums/religion-spirituality/27347-science-jacobs-spotted-sheep.html.
Available at: http://jbq.jewishbible.org/assets/Uploads/364/364_sheep.pdf.
- Detection and interpretation of genomic structural variation in mammals.Methods Mol Biol. 2012; 838: 225-248
- Personalizing oncology: perspectives and prospects.J Clin Oncol. 2013; 31: 1904-1911
- Pharmacogenetics and cardiovascular disease—implications for personalized medicine.Pharmacol Rev. 2013; 65: 987-1009
- Carotid intima media-thickness and genes involved in lipid metabolism in diabetic patients using statins—a pathway toward personalized medicine.Cardiovasc Hematol Agents Med Chem. 2013; 11: 3-8
Available at: http://en.wikipedia.org/wiki/Molecular_pathology.
- Promise of personalized omics to precision medicine.Wiley Interdiscip Rev Syst Biol Med. 2013; 5: 73-82
- Life on a microarray: assessing live cell functions in a microarray format.Cell Mol Life Sci. 2012; 69: 2717-2725
- The role of tissue microarray in the era of target-based agents.Expert Rev Anticancer Ther. 2011; 11: 859-869
Published online: October 11, 2013
© 2013 Published by Elsevier Inc.