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Review Article| Volume 33, ISSUE 4, P773-786, December 2013

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Clinical Implication of MicroRNAs in Molecular Pathology

  • Seema Sethi
    Affiliations
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA
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  • Shadan Ali
    Affiliations
    Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, 703 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201, USA
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  • Dejuan Kong
    Affiliations
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201, USA
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  • Philip A. Philip
    Affiliations
    Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201, USA
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  • Fazlul H. Sarkar
    Correspondence
    Corresponding author. Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201.
    Affiliations
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201, USA

    Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA
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Published:October 11, 2013DOI:https://doi.org/10.1016/j.cll.2013.08.001

      Keywords

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      References

        • Lei Z.
        • Tan I.B.
        • Das K.
        • et al.
        Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.
        Gastroenterology. 2013; 145: 554-565
        • Elghannam D.M.
        • Ibrahim L.
        • Ebrahim M.A.
        • et al.
        Association of MDR1 gene polymorphism (G2677T) with imatinib response in Egyptian chronic myeloid leukemia patients.
        Hematology. 2013; ([Epub ahead of print])
        • Tan J.
        • Yu Q.
        Molecular mechanisms of tumor resistance to PI3K-mTOR targeted cancer therapy.
        Chin J Cancer. 2013; 32: 376-379
        • Lv X.
        • Ma X.
        • Hu Y.
        Furthering the design and the discovery of small molecule ATP-competitive mTOR inhibitors as an effective cancer treatment.
        Expert Opin Drug Discov. 2013; 8: 991-1012
      1. Rai G, Vyjayanti VN, Dorjsuren D, et al. Small molecule inhibitors of the human apurinic/apyrimidinic endonuclease 1 (APE1). 2010.

        • Sethi S.
        • Kong D.
        • Land S.
        • et al.
        Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer.
        Am J Transl Res. 2013; 5: 200-211
        • Sethi S.
        • Sarkar F.H.
        Evolving concept of cancer stem cells: role of micro-RNAs and their implications in tumor aggressiveness.
        J Carcinogene Mutagene. 2011; : 005https://doi.org/10.4172/2157-2518.S1-005
        • Hassan O.
        • Ahmad A.
        • Sethi S.
        • et al.
        Recent updates on the role of microRNAs in prostate cancer.
        J Hematol Oncol. 2012; 5: 9
        • Bao L.
        • Yan Y.
        • Xu C.
        • et al.
        MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways.
        Cancer Lett. 2013; 337: 226-236
        • Lei H.
        • Zou D.
        • Li Z.
        • et al.
        MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation.
        PLoS One. 2013; 8: e60369
        • Shen S.N.
        • Wang L.F.
        • Jia Y.F.
        • et al.
        Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer.
        Diagn Pathol. 2013; 8: 69
        • Ali S.
        • Saleh H.
        • Sethi S.
        • et al.
        MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer.
        Br J Cancer. 2012; 107: 1354-1360
        • Qazi A.M.
        • Gruzdyn O.
        • Semaan A.
        • et al.
        Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101.
        Surgery. 2012; 152: 704-711
        • Ahmad A.
        • Sarkar S.H.
        • Bitar B.
        • et al.
        Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells.
        Mol Cancer Ther. 2012; 11: 2193-2201
        • Kong D.
        • Heath E.
        • Chen W.
        • et al.
        Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.
        PLoS One. 2012; 7: e33729
        • Ahmad A.
        • Aboukameel A.
        • Kong D.
        • et al.
        Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells.
        Cancer Res. 2011; 71: 3400-3409
        • Kong D.
        • Banerjee S.
        • Ahmad A.
        • et al.
        Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells.
        PLoS One. 2010; 5: e12445
        • Baraniskin A.
        • Kuhnhenn J.
        • Schlegel U.
        • et al.
        MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma.
        J Neurooncol. 2012; 109: 239-244
        • Brunet V.A.
        • Pericay C.
        • Moya I.
        • et al.
        microRNA expression profile in stage III colorectal cancer: circulating miR-18a and miR-29a as promising biomarkers.
        Oncol Rep. 2013; 30: 320-326
        • Ulivi P.
        • Foschi G.
        • Mengozzi M.
        • et al.
        Peripheral blood miR-328 expression as a potential biomarker for the early diagnosis of NSCLC.
        Int J Mol Sci. 2013; 14: 10332-10342
        • Bi S.
        • Cui Y.
        • Li L.
        Dumbbell probe-mediated cascade isothermal amplification: a novel strategy for label-free detection of microRNAs and its application to real sample assay.
        Anal Chim Acta. 2013; 760: 69-74
        • Gu L.Q.
        • Wanunu M.
        • Wang M.X.
        • et al.
        Detection of miRNAs with a nanopore single-molecule counter.
        Expert Rev Mol Diagn. 2012; 12: 573-584
        • Guan D.G.
        • Liao J.Y.
        • Qu Z.H.
        • et al.
        mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features.
        RNA Biol. 2011; 8: 922-934
        • Luo S.
        MicroRNA expression analysis using the Illumina microRNA-Seq Platform.
        Methods Mol Biol. 2012; 822: 183-188
        • Acunzo M.
        • Romano G.
        • Palmieri D.
        • et al.
        Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.
        Proc Natl Acad Sci U S A. 2013; 110: 8573-8578
        • Yang J.
        • Zhang W.
        New molecular insights into osteosarcoma targeted therapy.
        Curr Opin Oncol. 2013; 25: 398-406
        • Noguchi S.
        • Iwasaki J.
        • Kumazaki M.
        • et al.
        Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo.
        Mol Ther. 2013; 21: 1204-1211
        • Dang Y.
        • Luo D.
        • Rong M.
        • et al.
        Underexpression of miR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET.
        PLoS One. 2013; 8: e61054
        • Ali S.
        • Almhanna K.
        • Chen W.
        • et al.
        Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer.
        Am J Transl Res. 2010; 3: 28-47
        • Ali S.
        • Banerjee S.
        • Logna F.
        • et al.
        Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer.
        J Cell Physiol. 2012; 227: 3373-3380
        • Ali S.
        • Ahmad A.
        • Banerjee S.
        • et al.
        Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF.
        Cancer Res. 2010; 70: 3606-3617
        • Liang Y.
        • Ridzon D.
        • Wong L.
        • et al.
        Characterization of microRNA expression profiles in normal human tissues.
        BMC Genomics. 2007; 8: 166
        • Griffiths-Jones S.
        miRBase: microRNA sequences and annotation.
        Curr Protoc Bioinformatics. 2010; 29 (12.9.1–12.9.10)
        • Gall T.M.
        • Frampton A.E.
        • Krell J.
        • et al.
        Blood-based miRNAs as noninvasive diagnostic and surrogative biomarkers in colorectal cancer.
        Expert Rev Mol Diagn. 2013; 13: 141-145
        • Hermansen S.K.
        • Dahlrot R.H.
        • Nielsen B.S.
        • et al.
        MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas.
        J Neurooncol. 2013; 111: 71-81
        • Si H.
        • Sun X.
        • Chen Y.
        • et al.
        Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.
        J Cancer Res Clin Oncol. 2013; 139: 223-229
        • Sicard F.
        • Gayral M.
        • Lulka H.
        • et al.
        Targeting miR-21 for the therapy of pancreatic cancer.
        Mol Ther. 2013; 21: 986-994
        • Tang D.
        • Shen Y.
        • Wang M.
        • et al.
        Identification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer.
        Eur J Cancer Prev. 2013; ([Epub ahead of print])
        • Yang S.M.
        • Huang C.
        • Li X.F.
        • et al.
        miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN.
        Toxicology. 2013; 306: 162-168
        • Liu R.
        • Liao J.
        • Yang M.
        • et al.
        Circulating miR-155 expression in plasma: a potential biomarker for early diagnosis of esophageal cancer in humans.
        J Toxicol Environ Health A. 2012; 75: 1154-1162
        • Yang M.
        • Shen H.
        • Qiu C.
        • et al.
        High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer.
        Eur J Cancer. 2013; 49: 604-615
        • Zhang Y.
        • Roccaro A.M.
        • Rombaoa C.
        • et al.
        LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas.
        Blood. 2012; 120: 1678-1686
        • Yabushita S.
        • Fukamachi K.
        • Tanaka H.
        • et al.
        Circulating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.
        Pancreas. 2012; 41: 1013-1018
        • Ali S.
        • Ahmad A.
        • Aboukameel A.
        • et al.
        Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
        Cancer Lett. 2012; 319: 173-181
        • Bhutia Y.D.
        • Hung S.W.
        • Krentz M.
        • et al.
        Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein.
        PLoS One. 2013; 8: e53436
        • Hu X.
        • Guo J.
        • Zheng L.
        • et al.
        The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer.
        Mol Cancer Res. 2013; 11: 240-250
        • Kang H.W.
        • Crawford M.
        • Fabbri M.
        • et al.
        A mathematical model for microRNA in lung cancer.
        PLoS One. 2013; 8: e53663
        • Zaman M.S.
        • Maher D.M.
        • Khan S.
        • et al.
        Current status and implications of microRNAs in ovarian cancer diagnosis and therapy.
        J Ovarian Res. 2012; 5: 44
        • Jusufovic E.
        • Rijavec M.
        • Keser D.
        • et al.
        let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non–small–cell lung cancer.
        PLoS One. 2012; 7: e45577
        • Xia X.M.
        • Jin W.Y.
        • Shi R.Z.
        • et al.
        Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
        Oncol Lett. 2010; 1: 1045-1047
        • Vogt M.
        • Munding J.
        • Gruner M.
        • et al.
        Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas.
        Virchows Arch. 2011; 458: 313-322
        • Krutzfeldt J.
        • Rajewsky N.
        • Braich R.
        • et al.
        Silencing of microRNAs in vivo with 'antagomirs'.
        Nature. 2005; 438: 685-689
        • Callari M.
        • Dugo M.
        • Musella V.
        • et al.
        Comparison of microarray platforms for measuring differential microRNA expression in paired normal/cancer colon tissues.
        PLoS One. 2012; 7: e45105
        • Azmi A.S.
        • Ali S.
        • Banerjee S.
        • et al.
        Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism.
        Am J Transl Res. 2011; 3: 374-382
        • Lang M.F.
        • Yang S.
        • Zhao C.
        • et al.
        Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells.
        PLoS One. 2012; 7: e36248