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- Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.Chest. 1992; 101: 1656-1662
- Dear SIRS, I’m sorry to say that I don’t like you….Crit Care Med. 1997; 25: 372-374
- Inclusion criteria for clinical trials in sepsis: did the American College of Chest Physicians/Society of Critical care Medicine consensus conference definitions of sepsis have an impact?.Chest. 2005; 127: 242-245
- 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definition Conference.Crit Care Med. 2003; 31: 1250-1256
- Proof of principle: the predisposition, infection, response, organ failure sepsis staging system.Crit Care Med. 2011; 39: 322-327
- Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.Crit Care Med. 2001; 29: 1303-1310
- Epidemiology of sepsis in Germany: results from a national prospective multicenter study.Intensive Care Med. 2007; 33: 606-618
- Sepsis in European intensive care units: results of the SOAP study.Crit Care Med. 2006; 34: 344-353
- Deaths: preliminary data for 2011.Natl Vital Stat Rep. 2012; 61: 1-65
- Epidemiology and outcome of nosocomial and community-acquired bloodstream infection.J Clin Microbiol. 2003; 41: 3655-3660
- The epidemiology of sepsis in the United States from 1979 through 2000.N Engl J Med. 2003; 348: 1546-1554
- Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units.Intensive Care Med. 2004; 30: 589-596
- The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996-2004: secondary analysis of a high quality clinical database, the ICNARC case mix programme database.Crit Care. 2006; 10: R42
- The surviving sepsis campaign: results of an international guideline-based performance improvement program targeting severe sepsis.Crit Care Med. 2010; 38: 367-374
- Inpatient care for septicemia or sepsis: a challenge for patients and hospitals.NCHS Data Brief. 2011; (National Center for Health Statistics, Hyattsville (MD)): 1-8
- Epidemiology of sepsis in surgical patients.Surg Clin North Am. 2012; 92: 1425-1443
- Increasing rates of hospitalization due to septicemia in the US elderly population, 1986-1997.J Infect Dis. 2001; 183: 596-603
- The epidemiology of hospitalization of elderly Americans for septicemia or bacteremia in 1991-1998: application of Medicare claims data.Ann Epidemiol. 2001; 11: 118-126
- Economic aspects of severe sepsis.Pharmacoeconomics. 2004; 22: 793-813
- Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock.Crit Care Med. 2008; 36: 296-327
- Laboratory diagnosis of bacteremia and fungemia.Infect Dis Clin North Am. 2001; 15: 1009-1024
- Blood cultures: key elements for best practices and future directions.J Infect Chemother. 2010; 16: 301-316
- Blood culture contamination: a College of American Pathologists Q-Probes study involving 640 institutions and 497134 specimens from adult patients.Arch Pathol Lab Med. 1998; 122: 216-221
- Clinical significance of potential contaminants in blood cultures among patients in a medical center.J Microbiol Immunol Infect. 2007; 40: 438-444
- Predictive value of blood cultures positive for coagulase-negative staphylococci: implications for patient care and health care quality assurance.Clin Infect Dis. 2004; 39: 333-341
- Detection of bloodstream infection in adults: how many blood cultures are needed?.J Clin Microbiol. 2007; 45: 3546-3548
- Predicting bacteremia in hospitalized patients: a prospective validated model.Ann Intern Med. 1990; 113: 495-500
- Reducing blood culture contamination by a simple informational intervention.J Clin Microbiol. 2010; 48: 4552-4558
- Sir Isaac Newton, sepsis, SIRS, and CARS.Crit Care Med. 1996; 24: 1125-1128
- The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients.Clin Chest Med. 2008; 29: 617-625
- Clinical aspects: from systemic inflammation to “immuneparalysis”.Chem Immunol. 2000; 74: 162-177
- Impaired antigen presentation by human monocytes during endotoxin tolerance.Blood. 2000; 96: 218-223
- The pathophysiology and treatment of sepsis.N Engl J Med. 2003; 348: 138-150
- Biological perspectives: pathophysiology of sepsis.Am J Pathol. 2007; 170: 1435-1444
- Harmful molecular mechanisms in sepsis.Nat Rev Immunol. 2008; 8: 776-787
- Immunosuppression in patients who die of sepsis and multiple organ failure.JAMA. 2011; 306: 2594-2605
- Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.Clin Pharmacol Ther. 2001; 69: 89-95
- Biomarkers of sepsis.Crit Care Med. 2009; 37: 2290-2298
- The diagnostic role of procalcitonin and other biomarkers in discriminating infectious from non-infectious fever.J Infect. 2010; 60: 409-416
- Measures, markers, and mediators: toward a staging system for clinical sepsis: a report of the Fifth Toronto Sepsis Roundtable, Ontario, Canada, October 25–26, 2000.Crit Care Med. 2003; 31: 1560-1567
- Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis.Clin Infect Dis. 2004; 39: 206-217
- Biomarkers in the critically ill patient: C-reactive protein.Crit Care Clin. 2011; 27: 241-251
- C-reactive protein for detection and follow-up of bacterial and fungal infections in severely neutropenic patients with acute leukemia.Eur J Cancer Clin Oncol. 1985; 21: 557-562
- The utility of serum C-reactive protein in differentiating bacterial from nonbacterial pneumonia in children: a meta-analysis of 1230 children.Pediatr Infect Dis J. 2008; 27: 95-99
- Serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in healthy newborn infants and healthy young through elderly adults.Acta Paediatr. 2005; 94: 1198-1202
- C-reactive protein as a marker of infection in critically ill patients.Clin Microbiol Infect. 2005; 11: 101-108
- An update on C-reactive protein for intensivists.Anaesth Intensive Care. 2009; 37: 234-241
- A prospective evaluation of the Infection Probability Score (IPS) in the intensive care unit.J Infect. 2008; 56: 313-318
- Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study.Crit Care. 2006; 10: R63
- Is C-reactive protein a good prognostic marker in septic patients?.Intensive Care Med. 2009; 35: 909-913
- Diagnosis and follow-up of infections in intensive care patients: value of C-reactive protein compared with other clinical and biological variables.Crit Care Med. 2002; 30: 529-535
- The time course of blood C-reactive protein concentrations in relation to the response to initial antimicrobial therapy in patients with sepsis.Infection. 2008; 36: 213-219
- Procalcitonin and the role of biomarkers in the diagnosis and management of sepsis.Diagn Microbiol Infect Dis. 2012; 73: 221-227
- High serum procalcitonin concentrations in patients with sepsis and infection.Lancet. 1993; 341: 515-518
- In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue.Endocrinology. 2003; 144: 5578-5584
- Ubiquitous expression of the calcitonin I gene in multiple tissues in response to sepsis.J Clin Endocrinol Metab. 2001; 86: 396-404
- Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors.J Clin Endocrinol Metab. 2004; 89: 1512-1525
- High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration.J Leukoc Biol. 2002; 72: 643-649
- Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial.Chest. 2010; 138: 121-129
- Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department.Crit Care Med. 2010; 38: 457-463
- Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department.Am J Clin Pathol. 2011; 135: 182-189
- Diagnostic value of procalcitonin for bacterial infection in elderly patients in the emergency department.J Am Geriatr Soc. 2010; 58: 518-522
- Comparison between procalcitonin and C-reactive protein for early diagnosis of children with sepsis and septic shock.Inflamm Res. 2010; 59: 581-586
- Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci.Infection. 2007; 35: 352-355
- Procalcitonin test in the diagnosis of bacteremia: a meta-analysis.Ann Emerg Med. 2007; 50: 34-41
- Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis.Lancet Infect Dis. 2007; 7: 210-217
- Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis.Crit Care Med. 2006; 34: 1996-2003
- Diagnostic and prognostic biomarkers of sepsis in critical care.J Antimicrob Chemother. 2011; 66: 33-40
- Diagnostic efficacy and prognostic value of serum procalcitonin concentration in patients with suspected sepsis.J Intensive Care Med. 2009; 24: 63-71
- Use of procalcitonin to shorten antibiotic treatment duration in septic patients.Am J Respir Crit Care Med. 2008; 177: 498-505
- Procalcitonin to guide duration of antimicrobial therapy in intensive care units: a systematic review.Clin Infect Dis. 2011; 53: 379-387
- Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms.Arch Intern Med. 2011; 171: 1322-1331
- Participation of lipopolysaccharide-binding protein in lipopolysaccharide-dependent macrophage activation.Am J Respir Cell Mol Biol. 1992; 7: 239-245
- Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.J Exp Med. 1994; 180: 1025-1035
- Neutrophil adherence induced by lipopolysaccharide in vitro. Role of plasma component interaction with lipopolysaccharide.J Clin Invest. 1992; 90: 2526-2535
- Plasma lipopolysaccharide (LPS)-binding protein. A key component in macrophage recognition of gram-negative LPS.J Immunol. 1992; 149: 200-206
- Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock.J Infect Dis. 1999; 180: 1584-1589
- Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study.Crit Care. 2006; 10: R53
- Lipopolysaccharide-binding protein for monitoring of post-operative sepsis: complemental to C-reactive protein or redundant?.PLoS One. 2011; 6: e23615
- Serum lipopolysaccharide-binding protein levels predict severity of lung injury and mortality in patients with severe sepsis.PLoS One. 2009; 4: e6818
- Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?.Crit Care Med. 2008; 36: 2014-2022
- Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update.Crit Care Med. 2004; 32: 1928-1948
- The vasopressin system: physiology and clinical strategies.Anesthesiology. 2006; 105: 599-612
- Circulating vasopressin levels in septic shock.Crit Care Med. 2003; 31: 1752-1758
- Adrenomedullin, a multifunctional regulatory peptide.Endocr Rev. 2000; 21: 138-167
- Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis.J Clin Endocrinol Metab. 1996; 81: 1449-1453
- The pivotal role of adrenomedullin in producing hyperdynamic circulation during the early stage of sepsis.Arch Surg. 1998; 133: 1298-1304
- Pulmonary clearance of adrenomedullin is reduced during the late stage of sepsis.Biochim Biophys Acta. 1999; 1427: 315-321
- Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome.Am J Respir Crit Care Med. 1999; 160: 132-136
- Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study.Crit Care. 2005; 9: R816-R824
- Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients.Intensive Care Med. 2009; 35: 1859-1867
- Utility of procalcitonin (PCT) and mid regional pro-adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in emergency department (ED). A comparison with APACHE II score.BMC Infect Dis. 2012; 12: 184
- Procalcitonin and mid-regional pro-adrenomedullin test combination in sepsis diagnosis.Clin Chem Lab Med. 2012; ([Epub ahead of print])https://doi.org/10.1515/cclm-2012-0595
- Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation.Lancet. 1998; 352: 1271-1277
- Early detection of severe sepsis in the emergency room: diagnostic value of C-reactive protein, procalcitonin, and interleukin-6.Scand J Infect Dis. 2011; 43: 883-890
- A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.Crit Care Med. 2010; 38: 1685-1694
- The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer.J Pediatr Hematol Oncol. 2012; 34: 122-127
- A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis.Cytokine. 2012; 57: 332-336
- Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children.Crit Care. 2012; 16: R213
- Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality.Intensive Care Med. 2010; 36: 621-629
- PTX3 predicts severe disease in febrile patients in the emergency department.J Infect. 2010; 60: 122-127
- A rapid assay of endotoxin in whole blood using autologous neutrophil dependent chemiluminescence.J Immunol Methods. 1998; 212: 169-185
- Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study.J Infect Dis. 2004; 190: 527-534
- Combining intermediate levels of the endotoxin activity assay (EAA) with other biomarkers in the assessment of patients with sepsis: results of an observational study.Crit Care. 2012; 16: R88
- Biomarkers: diagnosis and risk assessment in sepsis.Clin Chest Med. 2008; 29: 591-603
- Multimarker panels in sepsis.Crit Care Clin. 2011; 27: 391-405
- Serial and panel analyses of biomarkers do not improve the prediction of bacteremia compared to one procalcitonin measurement.J Infect. 2012; 65: 292-301
- Clinical validation of the molecular-based BD GeneOhmTM StaphSR for the direct detection of Staphylococcus aureus and methicillin resistant Staphylococcus aureus in positive blood cultures.J Clin Microbiol. 2007; 45: 2191-2196
- Evaluation of the BD GeneOhm StaphSR assay for detection of methicillin resistant and methicillin-susceptible Staphylococcus aureus isolates from spiked positive blood culture bottles.J Clin Microbiol. 2009; 47: 1689-1694
- Failure of the BD GeneOhm StaphSR assay for direct detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates in positive blood cultures collected in the United States.J Clin Microbiol. 2009; 47: 3747-3748
- Genotypic and phenotypic characterization of methicillin-susceptible Staphylococcus aureus isolates misidentified as methicillin-resistant Staphylococcus aureus by the BD GeneOhm MRSA assay.J Clin Microbiol. 2011; 49: 1240-1244
- Cost effective modification of a commercial PCR-assay for detection of methicillin-resistant/susceptible Staphylococcus aureus from positive blood cultures.J Clin Microbiol. 2010; 48: 1408-1412
- Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA/SA skin and soft tissue and blood cultures assays.J Clin Microbiol. 2009; 47: 823-826
- Validation and implementation of the GeneXpert MRSA/SA blood culture assay in a pediatric setting.Am J Clin Pathol. 2011; 136: 690-694
- Evaluation of the Xpert MRSA/SA blood culture assay for the detection of Staphylococcus aureus including strains with reduced vancomycin susceptibility from blood culture specimens.Diagn Microbiol Infect Dis. 2012; 70: 404-407
- Value of Xpert MRSA/SA blood culture assay on the GeneXpert Dx system for rapid detection of Staphylococcus aureus and coagulase-negative staphylococci in patients with staphylococcal bacteremia.Diagn Microbiol Infect Dis. 2013; 75: 139-143
- Impact of an assay that enables rapid determination of Staphylococcus species and their drug susceptibility on the treatment of patients with positive blood culture results.Infect Control Hosp Epidemiol. 2010; 31: 1043-1048
- Applications of LightCycler Staphylococcus M-GRADE assay to detect Staphylococcus aureus and coagulase-negative staphylococci in clinical samples and in blood culture bottles.Infez Med. 2006; 14: 71-76
- Evaluation of the LightCycler Staphylococcus M GRADE kits on positive blood cultures that contained gram-positive cocci in clusters.J Clin Microbiol. 2005; 43: 6144-6146
- Comparison of four methods for rapid identification of Staphylococcus aureus from BACTEC 9240 blood culture system.Indian J Med Microbiol. 2011; 29: 42-46
- StaphPlex System for rapid and simultaneous identification of antibiotic resistance determinants and Panton-Valentine leukocidin detection of staphylococci from positive blood cultures.J Clin Microbiol. 2007; 45: 1867-1873
Nanosphere product [package insert]. 2012. Verigene Gram-Positive Blood Culture Nucleic Acid Test (BC-GP) Nanosphere, Inc. Northbrook, IL.
- Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies.J Med Microbiol. 2008; 57: 601-604
- Blood culture systems: rapid detection–how and why?.Int J Antimicrob Agents. 2009; 34: S13-S15
- Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study.Lancet. 2010; 375: 224-230
- Evaluation of the Hyplex BloodScreen multiplex PCR-enzyme-linked immunosorbent assay system for direct identification of gram-positive cocci and gram-negative bacilli from positive blood cultures.J Clin Microbiol. 2004; 42: 3147-3152
- Preliminary clinical study using a multiplex real-time PCR test for the detection of bacterial and fungal DNA directly in blood.Clin Microbiol Infect. 2010; 16: 774-779
- Diagnostic accuracy and potential clinical value of the LightCycler SeptiFast assay in the management of bloodstream infections occurring in neutropenic and critically ill patients.Int J Infect Dis. 2011; 15: e326-e331
- Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis.J Clin Microbiol. 2011; 49: 2252-2258
- Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis.J Clin Microbiol. 2009; 47: 2759-2765
- Evaluation of commercial universal rRNA gene PCR plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis.J Clin Microbiol. 2011; 49: 2919-2923
- The era of molecular and other non-culture based methods in diagnosis of sepsis.Clin Microbiol Rev. 2010; 23: 235-251
- DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients.PLoS One. 2012; 7: 338916
- New technology for rapid molecular diagnosis of bloodstream infections.Expert Rev Mol Diagn. 2010; 10: 399-415
- Use of PCR coupled with electrospray ionization mass spectrometry for rapid identification of bacterial and yeast bloodstream pathogens from blood culture bottles.J Clin Microbiol. 2011; 49: 345-353
- Detection and identification of Ehrlichia species in blood by use of PCR and electrospray ionization mass spectrometry.J Clin Microbiol. 2010; 48: 472-478
- Consequences of different diagnostic “gold standards” in test accuracy research: carpal tunnel syndrome as an example.Int J Epidemiol. 2005; 34: 953-955
- Sepsis: rethinking the approach to clinical research.J Leukoc Biol. 2008; 83: 471-482
Article info
Footnotes
S. Riedel has received research funding from Cubist Pharmaceuticals, Lexington, MA; Siemens Healthcare Diagnostics, Tarrytown, NY; Meridian Bioscience, Cincinnati, OH; Becton, Dickinson and Co, Sparks, MD; and Quidel, Inc, San Diego, CA.
K.C. Carroll has received research funding from BioFire, Inc, Salt Lake City, UT; Nanosphere, Inc, Northbrook, IL; and AdvanDx, Inc, Woburn, MA. She is also on the scientific advisory boards for Quidel, Inc, San Diego, CA, and NanoMR, Inc, Albuquerque, NM.