Review Article| Volume 32, ISSUE 4, P651-664, December 2012

Changing Trends in Laboratory Testing in the United States

A Personal, Historical Perspective


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        • Hudson K.L.
        • Murphy J.A.
        • Javitt G.H.
        • et al.
        Oversight of US genetic testing laboratories.
        Nat Biotechnol. 2006; 24: 1083-1090
        • Chang J.C.
        • Kan Y.W.
        A sensitive new prenatal test for sickle-cell anemia.
        N Engl J Med. 1982; 307: 30-32
        • Strom C.M.
        For the good of the patient: academic and commercial genetic testing laboratories: complementary if not complimentary.
        Personalized Medicine. 2007; 4: 489-495
        • Hofgärtner W.T.
        • Tait J.F.
        Characteristics of clinical molecular-genetic testing laboratories in the United States.
        Clin Chem. 1999; 45: 1288-1290
        • Merz J.F.
        • Kriss A.G.
        • Leonard D.G.
        • et al.
        Diagnostic testing fails the test.
        Nature. 2002; 415: 577-579
      1. Available at: Accessed June 19, 2012.

        • Strom C.M.
        • Clark D.D.
        • Hantash F.M.
        • et al.
        Direct visualization of cystic fibrosis transmembrane regulator mutations in the clinical laboratory setting.
        Clin Chem. 2004; 50: 836-845
        • Strom C.M.
        • Janeszco R.
        • Quan F.
        • et al.
        Technical validation of a luminex based multiplex assay for 40 mutations in the cystic fibrosis transmembrane regulator protein.
        J Mol Diagn. 2006; 8: 371-375
        • Sun W.
        Nucleic acid extraction and general procedures in molecular diagnostics—techniques and applications for the clinical laboratory.
        in: Grody W. Nakamura R. Kiechle F. Molecular diagnostics. Elsevier Press, Amsterdam, Holland2010: 35-58