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Review Article| Volume 31, ISSUE 2, P321-330, June 2011

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Desmoplastic Melanoma

  • Klaus J. Busam
    Correspondence
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.
    Affiliations
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA

    Weill Medical College of Cornell University, New York, NY, USA
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      References

        • Conley J.
        • Lattes R.
        • Orr W.
        Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma).
        Cancer. 1971; 28: 914-936
        • Reed R.J.
        • Leonard D.D.
        Neurotropic melanoma. A variant of desmoplastic melanoma.
        Am J Surg Pathol. 1979; 3: 301-311
        • Quinn M.J.
        • Crotty K.A.
        • Thompson J.F.
        • et al.
        Desmoplastic and desmoplastic neurotropic melanoma: experience with 280 patients.
        Cancer. 1998; 83: 1128-1135
        • McCarthy S.W.
        • Scolyer R.A.
        • Palmer A.A.
        Desmoplastic melanoma: a diagnostic trap for the unwary.
        Pathology. 2004; 36: 445-451
        • Busam K.J.
        • Mujumdar U.
        • Hummer A.J.
        • et al.
        Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors.
        Am J Surg Pathol. 2004; 28: 1518-1525
        • Skelton H.G.
        • Smith K.J.
        • Laskin W.B.
        • et al.
        Desmoplastic malignant melanoma.
        J Am Acad Dermatol. 1995; 32: 717-725
        • Hawkins W.G.
        • Busam K.J.
        • Ben-Porat L.
        • et al.
        Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma.
        Ann Surg Oncol. 2005; 12: 207-213
        • Chen J.Y.
        • Hruby G.
        • Scolyer R.A.
        • et al.
        Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases.
        Cancer. 2008; 113: 2770-2778
        • Su L.D.
        • Fullen D.R.
        • Lowe L.
        • et al.
        Desmoplastic and neurotropic melanoma.
        Cancer. 2004; 100: 598-604
        • Kilpatrick S.E.
        • White W.L.
        • Browne J.D.
        Desmoplastic malignant melanoma of the oral mucosa. An underrecognized diagnostic pitfall.
        Cancer. 1996; 78: 383-389
        • Wharton J.M.
        • Carlson J.A.
        • Mihm Jr., M.C.
        Desmoplastic malignant melanoma: diagnosis of early clinical lesions.
        Hum Pathol. 1999; 30: 537-542
        • Carlson J.A.
        • Dickersin G.R.
        • Sober A.J.
        • et al.
        Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases.
        Cancer. 1995; 75: 478-494
        • Sarode V.R.
        • Joshi K.
        • Ravichandran P.
        • et al.
        Myxoid variant of primary cutaneous malignant melanoma.
        Histopathology. 1992; 20: 186-187
        • Patel P.
        • Levin K.
        • Waltz K.
        • et al.
        Myxoid melanoma: immunohistochemical studies and a review of the literature.
        J Am Acad Dermatol. 2002; 46: 264-270
        • Hitchcock M.G.
        • McCalmont T.H.
        • White W.L.
        Cutaneous melanoma with myxoid features: twelve cases with differential diagnosis.
        Am J Surg Pathol. 1999; 23: 1506-1513
        • Allen P.W.
        Myxoid tumors of soft tissues.
        Pathol Annu. 1980; 15: 133-192
        • Rongioletti F.
        • Innocenzi D.
        Sclerosing ‘mucinous’ blue naevus.
        Br J Dermatol. 2003; 148: 1250-1252
        • Busam K.J.
        • Barnhill R.L.
        Dermal melanocytoses, blue nevi and related conditions.
        in: Busam K.J. Pathology of melanocytic nevi and malignant melanoma. Springer, New York2004: 199-222
        • Harris G.R.
        • Shea C.R.
        • Horenstein M.G.
        • et al.
        Desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma.
        Am J Surg Pathol. 1999; 23: 786-794
        • Liu J.
        • Cohen P.R.
        • Farhood A.
        Hyalinizing Spitz nevus: spindle and epithelioid cell nevus with paucicellular collagenous stroma.
        Southampt Med J. 2004; 97: 102-106
        • Kucher C.
        • Zhang P.J.
        • Pasha T.
        • et al.
        Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi.
        Am J Dermatopathol. 2004; 26: 452-457
        • Kaneishi N.K.
        • Cockerell C.J.
        Histologic differentiation of desmoplastic melanoma from cicatrices.
        Am J Dermatopathol. 1998; 20: 128-134
        • Spitz J.L.
        • Silvers D.N.
        Desmoplastic melanoma (or is it merely cicatrix?) arising at the site of biopsy within a conventional melanoma: pitfalls in the diagnosis desmoplastic melanoma.
        Cutis. 1995; 55: 40-44
        • Busam K.J.
        • Iversen K.
        • Coplan K.C.
        • et al.
        Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
        Am J Surg Pathol. 2001; 25: 197-204
        • Winnepenninckx V.
        • De Vos R.
        • Stas M.
        • et al.
        New phenotypical and ultrastructural findings in spindle cell (desmoplastic/neurotropic) melanoma.
        Appl Immunohistochem Mol Morphol. 2003; 11: 319-325
        • Diaz-Cascajo C.
        • Borghi S.
        • Weyers W.
        Desmoplastic leiomyosarcoma of the skin.
        Am J Dermatopathol. 2000; 22: 251-255
        • Kane C.L.
        • Keehn C.A.
        • Smithberger E.
        • et al.
        Histopathology of cutaneous squamous cell carcinoma and its variants.
        Semin Cutan Med Surg. 2004; 23: 54-61
        • Hoang M.P.
        • Selim M.A.
        • Bentley R.C.
        • et al.
        CD34 expression in desmoplastic melanoma.
        J Cutan Pathol. 2001; 28: 508-512
        • Riccioni L.
        • Di Tommaso L.
        • Collina G.
        Actin-rich desmoplastic malignant melanoma: report of three cases.
        Am J Dermatopathol. 1999; 21: 537-541
        • Kanik A.B.
        • Yaar M.
        • Bhawan J.
        p75 nerve growth factor receptor staining helps identify desmoplastic and neurotropic melanoma.
        J Cutan Pathol. 1996; 23: 205-210
        • Pawlik T.M.
        • Ross M.I.
        • Prieto V.G.
        • et al.
        Assessment of the role of sentinel lymph node biopsy for primary cutaneous desmoplastic melanoma.
        Cancer. 2006; 106: 900-906
        • George E.
        • McClain S.E.
        • Slingluff C.L.
        • et al.
        Subclassification of desmoplastic melanoma: pure and mixed variants have significantly different capacities for lymph node metastasis.
        J Cutan Pathol. 2009; 36: 425-432
        • Jain S.
        • Allen P.W.
        Desmoplastic malignant melanoma and its variants. A study of 45 cases.
        Am J Surg Pathol. 1989; 13: 358-373
        • Smithers B.M.
        • McLeod G.R.
        • Little J.H.
        Desmoplastic melanoma: patterns of recurrence.
        World J Surg. 1992; 16: 186-190
        • Walsh N.M.
        • Roberts J.T.
        • Orr W.
        • et al.
        Desmoplastic malignant melanoma. A clinicopathologic study of 14 cases.
        Arch Pathol Lab Med. 1988; 112: 922-927
        • Baer S.C.
        • Schultz D.
        • Synnestvedt M.
        • et al.
        Desmoplasia and neurotropism. Prognostic variables in patients with stage I melanoma.
        Cancer. 1995; 76: 2242-2247
        • Livestro D.P.
        • Muzikansky A.
        • Kaine E.M.
        • et al.
        Biology of desmoplastic melanoma: a case-control comparison with other melanomas.
        J Clin Oncol. 2005; 23: 6739-6746
        • Spatz A.
        • Shaw H.M.
        • Crotty K.A.
        • et al.
        Analysis of histopathological factors associated with prolonged survival of 10 years or more for patients with thick melanomas (>5 mm).
        Histopathology. 1998; 33: 406-413
        • Gyorki D.E.
        • Busam K.
        • Panageas K.
        • et al.
        Sentinel lymph node biopsy for patients with cutaneous desmoplastic melanoma.
        Ann Surg Oncol. 2003; 10: 403-407
        • Thelmo M.C.
        • Sagebiel R.W.
        • Treseler P.A.
        • et al.
        Evaluation of sentinel lymph node status in spindle cell melanomas.
        J Am Acad Dermatol. 2001; 44: 451-455
        • Jaroszewski D.E.
        • Pockaj B.A.
        • DiCaudo D.J.
        • et al.
        The clinical behavior of desmoplastic melanoma.
        Am J Surg. 2001; 182: 590-595