Advertisement
Review Article| Volume 31, ISSUE 2, P289-300, June 2011

Melanoma Margin Assessment

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Cochran A.J.
        Prudent margins for melanocytic lesions.
        Eur J Plast Surg. 2001; 24: 78-79
        • Abide J.M.
        • Nahai F.
        • Bennet R.G.
        The meaning of surgical margins.
        Plast Reconstr Surg. 1984; 73: 492-496
        • Bennett R.G.
        The meaning and significance of tissue margins.
        Adv Dermatol. 1989; 4: 343-355
        • Rapini R.P.
        Comparison of methods for checking surgical margins.
        J Am Acad Dermatol. 1990; 23: 288-294
        • Shriner D.L.
        • McCoy D.K.
        • Goldberg D.J.
        • et al.
        Mohs micrographic surgery.
        J Am Acad Dermatol. 1998; 39: 79-97
        • Kimyai-Asadi A.
        • Katz T.
        • Goldberg L.H.
        • et al.
        Margin involvement after the excision of melanoma in situ: the need for complete en face examination of the surgical margins.
        Dermatol Surg. 2007; 33: 1434-1439
        • Breuninger H.
        • Schlagenhauff B.
        • Stroebel W.
        • et al.
        Patterns of local horizontal spread of melanomas: consequences for surgery and histopathologic evaluation.
        Am J Surg Pathol. 1999; 23: 1493-1498
        • Barnhill R.L.
        • Piepkorn M.
        • Busam K.J.
        Pathology of melanocytic nevi and malignant melanoma.
        2nd edition. Springer, New York2004 (p. 278)
        • Agarwal-Antal N.
        • Bowen G.M.
        • Gerwels J.W.
        Histologic evaluation of lentigo maligna with permanent sections: implications regarding current guidelines.
        J Am Acad Dermatol. 2002; 47: 743-748
        • Ackerman A.B.
        • Briggs P.L.
        • Bravo F.
        Differential diagnosis in dermatopathology III.
        Lea & Febiger, Philadelphia1993 (p. 166–9)
        • Weyers W.
        • Bonczkowitz M.
        • Weyers I.
        • et al.
        Melanoma in situ versus melanocytic hyperplasia in sun-damaged skin: assessment of the significance of histopathologic criteria for the differential diagnosis.
        Am J Dermatopathol. 1996; 18: 560-566
        • Acker S.M.
        • Nicholson J.H.
        • Rust P.F.
        • et al.
        Morphometric discrimination of melanoma in situ of sun-damaged skin from chronically sun-damaged skin.
        J Am Acad Dermatol. 1998; 39: 239-245
        • Barlow J.O.
        • Maize Sr., J.M.
        • Lang P.G.
        The density and distribution of melanocytes adjacent to melanoma and non-melanoma skin cancers.
        Dermatol Surg. 2007; 33: 199-207
        • Cohen L.M.
        The starburst giant cell is useful for distinguishing lentigo maligna from photodamaged skin.
        J Am Acad Dermatol. 1996; 35: 962-968
        • Farrahi F.
        • Egbert B.M.
        • Swetter S.M.
        Histologic similarities between lentigo maligna and dysplastic nevus: importance of clinicopathologic distinction.
        J Cutan Pathol. 2005; 32: 405-412
        • Hendi A.
        • Brodland D.G.
        • Zitelli J.A.
        Melanocytes in long-standing sun-exposed skin. Quantitative analysis using the MART-1 immunostain.
        Arch Dermatol. 2006; 142: 871-876
        • Andersen W.K.
        • Labadie R.R.
        • Bhawan J.
        Histopathology of solar lentigines of the face: a quantitative study.
        J Am Acad Dermatol. 1997; 36: 444-447
        • Dalton S.R.
        • Gardner T.L.
        • Libow L.F.
        • et al.
        Contiguous lesions in lentigo maligna.
        J Am Acad Dermatol. 2005; 52: 859-862
        • Somach S.C.
        • Taira J.W.
        • Pitha J.V.
        • et al.
        Pigmented lesions in actinically damaged skin. Histopathologic comparison of biopsy and excisional specimens.
        Arch Dermatol. 1996; 132: 1297-1302
        • Wong C.K.
        A study of melanocytes in the normal skin surrounding malignant melanoma.
        Dermatologica. 1970; 141: 215-225
        • Fallowfield M.E.
        • Cook M.G.
        Epidermal melanocytes adjacent to melanoma and the field change effect.
        Histopathology. 1990; 17: 397-400
        • Bastian B.C.
        • Kashani-Sabet M.
        • Hamm H.
        • et al.
        Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin.
        Cancer Res. 2000; 60: 1968-1973
        • North J.P.
        • Kageshita T.
        • Pinkel D.
        • et al.
        Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma.
        J Invest Dermatol. 2008; 128: 2024-2030
        • Fallowfield M.E.
        • Cook M.G.
        Re-excisions of scar in primary cutaneous melanoma: a histopathological study.
        Br J Dermatol. 1992; 126: 47-51
        • Duve S.
        • Schmoeckel C.
        • Burgdorf W.
        Melanocytic hyperplasia in scars: a histopathological investigation of 722 cases.
        Am J Dermatopathol. 1996; 18: 236-240
        • Dalton S.R.
        • Baptista M.A.
        • Libow L.F.
        • et al.
        Lichenoid tissue reaction in malignant melanoma, a potential diagnostic pitfall.
        Am J Clin Pathol. 2002; 117: 766-770
        • Maize J.C.
        • Resneck J.S.
        • Shapiro P.E.
        • et al.
        Ducking stray “magic bullets”: a Melan-A alert.
        Am J Dermatopathol. 2003; 25: 162-165
        • Robson A.
        • Allen P.
        • Hollowood K.
        S100 expression in cutaneous scars: a potential diagnostic pitfall in the diagnosis of desmoplastic melanoma.
        Histopathology. 2001; 38: 135-140
        • Chorny J.A.
        • Barr R.J.
        S100-positive spindle cells in scars: a diagnostic pitfall in the re-excision of desmoplastic melanoma.
        Am J Dermatopathol. 2002; 24: 309-312
        • Pitman G.H.
        • Kopf A.W.
        • Bart R.S.
        • et al.
        Treatment of lentigo maligna and lentigo maligna melanoma.
        J Dermatol Surg Oncol. 1979; 5: 727-737
        • Coleman III, W.P.
        • Davis R.S.
        • Reed R.J.
        • et al.
        Treatment of lentigo maligna and lentigo maligna melanoma.
        J Dermatol Surg Oncol. 1980; 6: 476-479
        • Karakousis C.P.
        • Balch C.M.
        • Urist M.M.
        • et al.
        Local recurrence in malignant melanoma: long term results of the multiinstitutional randomized surgical trial.
        Ann Surg Oncol. 1996; 3: 446-452
        • Osborne J.E.
        • Hutchinson P.E.
        A follow-up study to investigate the efficacy of initial treatment of lentigo maligna with surgical excision.
        Br J Plast Surg. 2002; 55: 611-615
        • Zitelli J.A.
        • Brown C.D.
        • Hanusa B.H.
        Surgical margins for excision of primary cutaneous melanoma.
        J Am Acad Dermatol. 1997; 37: 422-429
        • Robinson J.K.
        Margin control for lentigo maligna.
        J Am Acad Dermatol. 1994; 31: 79-85
        • Cohen L.M.
        • McCall M.W.
        • Hodge S.J.
        • et al.
        Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs micrographic surgery aided by rush permanent sections.
        Cancer. 1994; 73: 2964-2970
        • Bub J.L.
        • Berg D.
        • Slee A.
        • et al.
        Management of lentigo maligna and lentigo maligna melanoma with staged excision. A 5-year follow-up.
        Arch Dermatol. 2004; 140: 552-558
        • Moehrle M.
        • Dietz K.
        • Garbe C.
        • et al.
        Conventional histology vs. three-dimensional histology in lentigo maligna melanoma.
        Br J Dermatol. 2006; 154: 453-459
        • Zitelli J.A.
        • Brown C.D.
        • Hanusa B.H.
        Mohs micrographic surgery for the treatment of primary cutaneous melanoma.
        J Am Acad Dermatol. 1997; 37: 236-245
        • Clayton B.D.
        • Leshin B.
        • Hitchcock M.G.
        • et al.
        Utility of rush paraffin-embedded tangential sections in the management of cutaneous neoplasms.
        Dermatol Surg. 2000; 26: 671-678
        • Johnson T.M.
        • Headington J.T.
        • Baker S.R.
        • et al.
        Usefulness of the staged excision for lentigo maligna and lentigo maligna melanoma: the “square procedure”.
        J Am Acad Dermatol. 1997; 37: 758-764
        • Breuninger H.
        • Schaumberg-Lever G.
        Control of excisional margins by conventional histopathological techniques in the treatment of skin tumours. An alternative to the Mohs' technique.
        J Pathol. 1988; 154: 167-171
        • Prieto V.G.
        • Argenyi Z.B.
        • Barnhill R.B.
        • et al.
        Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions?.
        Am J Clin Pathol. 2003; 120: 203-208
        • Zitelli J.A.
        • Moy R.L.
        • Abell E.
        The reliability of frozen sections in the evaluation of surgical margins for melanoma.
        J Am Acad Dermatol. 1991; 24: 102-106
        • Bienert T.N.
        • Trotter M.J.
        • Arlette J.P.
        Treatment of cutaneous melanoma of the face by Mohs micrographic surgery.
        J Cutan Med Surg. 2003; 7: 25-30
        • Barlow R.J.
        • White C.R.
        • Swanson N.A.
        Mohs' micrographic surgery using frozen sections alone may be unsuitable for detecting single atypical melanocytes at the margins of melanoma in situ.
        Br J Dermatol. 2002; 146: 290-294
        • Thosani M.K.
        • Marghoob A.
        • Chen C.S.J.
        Current progress in immunostains in Mohs micrographic surgery: a review.
        Dermatol Surg. 2008; 34: 1621-1636
        • El Shabrawi-Caelen L.
        • Kerl H.
        • Cerroni L.
        Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis.
        Am J Dermatopathol. 2004; 26: 364-366
        • Wlitz K.L.
        • Qureshi H.
        • Patterson J.W.
        • et al.
        Immunostaining for MART-1 in interpretation of problematic intra-epidermal pigmented lesions.
        J Cutan Pathol. 2007; 34: 601-605
        • Helm K.
        • Findeis-Hosey J.
        Immunohistochemistry of pigmented actinic keratoses, actinic keratoses, melanoma in situ and solar lentigines with Melan-A.
        J Cutan Pathol. 2008; 35: 931-934
        • Kelley L.C.
        • Starkus L.
        Immunohistochemical staining of lentigo maligna during Mohs micrographic surgery using MART-1.
        J Am Acad Dermatol. 2002; 46: 78-84