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References
- Task Force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV-TR.4th edition. American Psychiatric Association, Washington, DC2000
- Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions.Arch Gen Psychiatry. 2004; 61: 1107-1115
- Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.JAMA. 1990; 264: 2511-2518
- Treatment for co-occurring mental and substance use disorders in five state Medicaid programs.Psychiatr Serv. 2007; 58: 942-948
- Smoking and mental illness: a population-based prevalence study.JAMA. 2000; 284: 2606-2610
- Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states.Prev Chronic Dis. 2006; 3: A42
- Morbidity and mortality in people with serious mental illness.National Association of State Mental Health Program Directors, Alexandria (VA)2006
- The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder.J Clin Psychiatry. 2006; 67: 1907-1911
- Genome-wide search for genes affecting the risk for alcohol dependence.Am J Med Genet. 1998; 81: 207-215
- Ethnic differences in alcohol sensitivity.Science. 1972; 175: 449-450
- Genetic studies on alcohol-metabolizing enzymes: detection of isozymes in human hair roots.Enzyme. 1980; 25: 281-286
- Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan.Lancet. 1982; 2: 827
- The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.Alcohol Res Health. 2007; 30: 5-13
- The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination.Ann Hum Genet. 2004; 68: 93-109
- Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.Am J Hum Genet. 1999; 65: 795-807
- Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.Psychol Bull. 2006; 132: 607-621
- Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.Am J Hum Genet. 1991; 48: 677-681
- Aldehyde dehydrogenase genotypes in Japanese alcoholics.Lancet. 1994; 343: 741-742
- Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations.Am J Hum Genet. 2002; 71 ([author reply: 1250–1]): 1247-1250
- Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.Am J Hum Genet. 2004; 74: 705-714
- Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.Behav Genet. 2006; 36: 640-650
- Allelic and haplotypic association of GABRA2 with alcohol dependence.Am J Med Genet B Neuropsychiatr Genet. 2004; 129: 104-109
- Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis.Psychiatr Genet. 2006; 16: 9-17
- GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence.J Psychiatr Res. 2008; 42: 184-191
- Ethanol and the GABA receptor complex: studies with the partial inverse benzodiazepine receptor agonist Ro 15-4513.Pharmacol Biochem Behav. 1988; 31: 767-772
- Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats.Pharmacol Biochem Behav. 1993; 46: 179-182
- Genome-wide association study of alcohol dependence.Arch Gen Psychiatry. 2009; 66: 773-784
- Multiple ADH genes are associated with upper aerodigestive cancers.Nat Genet. 2008; 40: 707-709
- Heritability of smoking initiation and nicotine dependence.Behav Genet. 2005; 35: 397-406
- Novel genes identified in a high-density genome wide association study for nicotine dependence.Hum Mol Genet. 2007; 16: 24-35
- Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.Hum Mol Genet. 2007; 16: 36-49
- The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Cancer Res. 2009; 69: 6848-6856
- The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.J Natl Cancer Inst. 2008; 100: 1552-1556
- A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.Nature. 2008; 452: 638-642
- A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.PLoS Genet. 2008; 4: e1000125
- Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.Mol Psychiatry. 2008; 13: 368-373
- Variants in nicotinic receptors and risk for nicotine dependence.Am J Psychiatry. 2008; 165: 1163-1171
- Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.Hum Mol Genet. 2009; 18: 3125-3135
- Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine.Am J Med Genet B Neuropsychiatr Genet. 2007; 144: 596-604
- Association of CHRN genes with “dizziness” to tobacco.Am J Med Genet B Neuropsychiatr Genet. 2010; 153B: 600-609
- Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with ‘pleasurable buzz’ during early experimentation with smoking.Addiction. 2008; 103: 1544-1552
- Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes.Biol Psychiatry. 2009; 65: 691-695
- Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.Nicotine Tob Res. 2009; 11: 785-796
- A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.Hum Mol Genet. 2009; 18: 2922-2927
- A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.Nature. 2008; 452: 633-637
- Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.Nat Genet. 2008; 40: 616-622
- A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.PLoS Genet. 2009; 5: e1000421
- Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.Cancer Res. 2008; 68: 9137-9140
Substance Abuse and Mental Health Services Administration, Office of Applied Studies (2008). Results from the 2007 National Survey on Drug Use and Health: National Findings (NSDUH Series H-34, DHHS Publication No. SMA 08-4343). Rockville, MD. Available at: http://www.oas.samhsa.gov/NSDUH/2k7NSDUH/2k7results.cfm. Accessed October 16, 2009.
- Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism.Arch Gen Psychiatry. 1998; 55: 982-988
- A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence.Biol Psychiatry. 2008; 64: 922-929
- Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.Mol Psychiatry. 2009; 14: 501-510
- Cigarette smoking and incidence of first depressive episode: an 11-year, population-based follow-up study.Am J Epidemiol. 2006; 163: 421-432
- Major depression and stages of smoking. A longitudinal investigation.Arch Gen Psychiatry. 1998; 55: 161-166
- Cigarette smoking, major depression, and other psychiatric disorders among adolescents.J Am Acad Child Adolesc Psychiatry. 1996; 35: 1602-1610
- Smoking and major depression. A causal analysis.Arch Gen Psychiatry. 1993; 50: 36-43
- Depressive symptoms and cigarette smoking among teens.Pediatrics. 2000; 106: 748-755
- The consequences in young adulthood of adolescent drug involvement. An overview.Arch Gen Psychiatry. 1986; 43: 746-754
- Tobacco smoking and depressed mood in late childhood and early adolescence.Am J Public Health. 1999; 89: 1837-1840
- Daily smoking and the subsequent onset of psychiatric disorders.Psychol Med. 2004; 34: 323-333
- Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.Lancet. 2009; 373: 234-239
- Unipolar depressive disorders have a common genotype.J Affect Disord. 2009; 117: 30-41
- Convergent genome wide association results for bipolar disorder and substance dependence.Am J Med Genet B Neuropsychiatr Genet. 2009; 150: 182-190
Article info
Footnotes
A version of this article originally appeared in the March 2010 issue of Psychiatric Clinics of North America.
Disclosures: Dr L Bierut is listed as an inventor on a patent “Markers of Addiction” (US 20070258898), covering the use of certain single nucleotide polymorphisms in determining the diagnosis, prognosis, and treatment of addiction. Dr Bierut acted as a consultant for Pfizer, Inc in 2008.
Funding support: Collaborative Genetic Study of Nicotine Dependence P01 CA89392 (National Cancer Institute), Study of Addiction: Genetics and Environment U01 HG004422 (National Human Genome Research Institute), Case Control Candidate Gene Study of Addiction R01 DA19963 (National Institute on Drug Abuse), Human Genetics of Addiction: A Study of Common and Specific Factors K02 DA021237 (National Institute on Drug Abuse), Collaborative Study on the Genetics of Alcoholism U10 AA008401 (National Institute on Alcohol Abuse and Alcoholism).
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© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
