Review Article| Volume 30, ISSUE 3, P721-725, September 2010

Screening for Open Neural Tube Defects


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.


      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Brock D.J.
        • Bolton A.E.
        • Monaghan J.M.
        Prenatal diagnosis of anencephaly through maternal serum-alphafetoprotein measurement.
        Lancet. 1973; 2: 923-924
        • Macri J.N.
        • Weiss R.R.
        • Schell N.B.
        • et al.
        Progress in screening for neural tube defects.
        JAMA. 1977; 237: 2187
        • Merkatz I.R.
        • Nitowsky H.M.
        • Macri J.N.
        • et al.
        An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities.
        Am J Obstet Gynecol. 1984; 148: 886-894
        • Macri J.N.
        • Anderson R.W.
        • Krantz D.A.
        • et al.
        Prenatal maternal dried blood screening with alpha-fetoprotein and free beta-human chorionic gonadotropin for open neural tube defect and Down syndrome.
        Am J Obstet Gynecol. 1996; 174: 566-572
        • Wald N.
        • Cuckle H.
        • Boreham J.
        • et al.
        The effect of maternal weight on maternal serum alpha-fetoprotein levels.
        Br J Obstet Gynaecol. 1981; 88: 1094-1096
        • Mills J.L.
        • Knopp R.H.
        • Simpson J.L.
        • et al.
        Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis.
        N Engl J Med. 1988; 318: 671-676
        • Henriques C.U.
        • Damm P.
        • Tabor A.
        • et al.
        Decreased alpha-fetoprotein in amniotic fluid and maternal serum in diabetic pregnancy.
        Obstet Gynecol. 1993; 82: 960-964
        • Sancken U.
        • Bartels I.
        Biochemical screening for chromosomal disorders and neural tube defects (NTD): is adjustment of maternal alpha-fetoprotein (AFP) still appropriate in insulin-dependent diabetes mellitus (IDDM)?.
        Prenat Diagn. 2001; 21: 383-386
      1. Fourth report of the UK collaborative study on alpha-fetoprotein in relation to neural tube defects. Estimating an individual's risk of having a fetus with open Spina Bifida and the value of repeat alpha-fetoprotein testing.
        J Epidemiol Community Health. 1982; 36: 87-95
        • Milunsky A.
        • Jick S.S.
        • Bruell C.L.
        • et al.
        Predictive values, relative risks, and overall benefits of high and low maternal serum alpha-fetoprotein screening in singleton pregnancies: new epidemiologic data.
        Am J Obstet Gynecol. 1989; 161: 291-297
        • Cuckle H.
        • Wald N.
        • Stevenson J.D.
        • et al.
        Maternal serum alpha-fetoprotein screening for open neural tube defects in twin pregnancies.
        Prenat Diagn. 1990; 10: 71-77
        • Greenberg F.
        • James L.M.
        • Oakley Jr., G.P.
        Estimates of birth prevalence rates of spina bifida in the United States from computer-generated maps.
        Am J Obstet Gynecol. 1983; 145: 570-573
        • Main D.M.
        • Mennuti M.T.
        Neural tube defects: issues in prenatal diagnosis and counseling.
        Obstet Gynecol. 1986; 1: 67
        • Robert E.
        • Guibaud P.
        Maternal valproic acid and congenital neural tube defects.
        Lancet. 1982; 320: 937
        • Rosa F.W.
        Spina bifida in infants of women treated with carbamazepine during pregnancy.
        N Engl J Med. 1991; 324: 675-677
        • Centers for Disease Control (CDC)
        Use of folic acid for prevention of spina bifida and other neural tube defects—1983–1991.
        MMWR Morb Mortal Wkly Rep. 1991; 40: 513-516
        • Johnson S.P.
        • Sebire N.J.
        • Snijders R.J.
        • et al.
        Ultrasound screening for anencephaly at 10–14 weeks of gestation.
        Ultrasound Obstet Gynecol. 1997; 9: 14-16