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Review Article| Volume 30, ISSUE 1, P161-177, March 2010

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Ebola and Marburg Hemorrhagic Fever

  • Amy L. Hartman
    Correspondence
    Corresponding author. University of Pittsburgh, Regional Biocontainment Laboratory, Center for Vaccine Research, 9015 Biomedical Science Tower 3, 3501 5th Avenue, Pittsburgh, PA 15261.
    Affiliations
    University of Pittsburgh, Regional Biocontainment Laboratory, Center for Vaccine Research, 9015 Biomedical Science Tower 3, 3501 5th Avenue, Pittsburgh, PA 15261, USA

    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Search for articles by this author
  • Jonathan S. Towner
    Affiliations
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, MS G-14, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
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  • Stuart T. Nichol
    Affiliations
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, MS G-14, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
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      Keywords

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      References

        • Regnery R.L.
        • Johnson K.M.
        • Kiley M.P.
        Virion nucleic acid of Ebola virus.
        J Virol. 1980; 36: 465-469
        • Suzuki Y.
        • Gojobori T.
        The origin and evolution of Ebola and Marburg viruses.
        Mol Biol Evol. 1997; 14: 800-806
        • Towner J.S.
        • Sealy T.K.
        • Khristova M.L.
        • et al.
        Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda.
        PLoS Pathog. 2008; 4: e1000212
        • Formenty P.
        • Hatz C.
        • Le Guenno B.
        • et al.
        Human infection due to Ebola virus, subtype Cote d'Ivoire: clinical and biologic presentation.
        J Infect Dis. 1999; 179: S48-S53
        • World Health Organization
        Ebola Reston in pigs and humans in the Philippines: update.
        (Available at:) (Accessed April 27, 2009)
        • Centers for Disease Control and Prevention
        Marburg hemorrhagic fever, imported case—United States.
        (Available at:) (Accessed June 20, 2009)
        • World Health Organization
        Epidemic and pandemic alert and response (EPR): case of Marburg haemorrhagic fever imported into the Netherlands from Uganda.
        (Available at:) (Accessed June 20, 2009)
        • US Department of Health and Human Services
        Biosafety in microbiological and biomedical laboratories.
        5th edition. U.S. Government Printing Office, Washington, DC2007
        • Sanchez A.
        • Geisbert T.W.
        • Feldmann H.
        Filoviridae: Marburg and Ebola viruses.
        in: Knipe B.M. Howley P.M. Griffen D.E. Fields virology. 5th edition. Lippincott-Raven, Philadelphia2007: 1409-1448
        • Colebunders R.
        • Tshomba A.
        • Van Kerkhove M.D.
        • et al.
        Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment.
        J Infect Dis. 2007; 196: S148-S153
        • Ksiazek T.G.
        • Rollin P.E.
        • Williams A.J.
        • et al.
        Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995.
        J Infect Dis. 1999; 179: S177-S187
        • Towner J.S.
        • Rollin P.E.
        • Bausch D.G.
        • et al.
        Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome.
        J Virol. 2004; 78: 4330-4341
        • Bwaka M.A.
        • Bonnet M.J.
        • Calain P.
        • et al.
        Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients.
        J Infect Dis. 1999; 179: S1-S7
        • Zaki S.R.
        • Goldsmith C.S.
        Pathologic features of filovirus infections in humans.
        Curr Top Microbiol Immunol. 1999; 235: 97-116
        • Smith D.H.
        • Johnson B.K.
        • Isaacson M.
        • et al.
        Marburg-virus disease in Kenya.
        Lancet. 1982; 1: 816-820
        • Emond R.T.
        • Evans B.
        • Bowen E.T.
        • et al.
        A case of Ebola virus infection.
        Br Med J. 1977; 2: 541-544
        • Rowe A.K.
        • Bertolli J.
        • Khan A.S.
        • et al.
        Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidemies a Kikwit.
        J Infect Dis. 1999; 179: S28-S35
        • Bray M.
        • Geisbert T.W.
        Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever.
        Int J Biochem Cell Biol. 2005; 37: 1560-1566
        • Geisbert T.W.
        • Hensley L.E.
        • Larsen T.
        • et al.
        Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
        Am J Pathol. 2003; 163: 2347-2370
        • Geisbert T.W.
        • Young H.A.
        • Jahrling P.B.
        • et al.
        Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event.
        J Infect Dis. 2003; 188: 1618-1629
        • Simmons G.
        • Reeves J.D.
        • Grogan C.C.
        • et al.
        DC-SIGN and DC-SIGNR bind Ebola glycoproteins and enhance infection of macrophages and endothelial cells.
        Virology. 2003; 305: 115-123
        • Baize S.
        • Leroy E.M.
        • Georges-Courbot M.C.
        • et al.
        Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients.
        Nat Med. 1999; 5: 423-426
        • Gupta M.
        • Mahanty S.
        • Ahmed R.
        • et al.
        Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with Ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro.
        Virology. 2001; 284: 20-25
        • Bosio C.M.
        • Aman M.J.
        • Grogan C.
        • et al.
        Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation.
        J Infect Dis. 2003; 188: 1630-1638
        • Mahanty S.
        • Hutchinson K.
        • Agarwal S.
        • et al.
        Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses.
        J Immunol. 2003; 170: 2797-2801
        • Geisbert T.W.
        • Hensley L.E.
        • Gibb T.R.
        • et al.
        Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses.
        Lab Invest. 2000; 80: 171-186
        • Harcourt B.H.
        • Sanchez A.
        • Offermann M.K.
        Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells.
        J Virol. 1999; 73: 3491-3496
        • Hartman A.L.
        • Bird B.H.
        • Towner J.S.
        • et al.
        Inhibition of IRF-3 activation by VP35 is critical for the high virulence of Ebola virus.
        J Virol. 2008; 82: 2699-2704
        • Hartman A.L.
        • Towner J.S.
        • Nichol S.T.
        A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus.
        Virology. 2004; 328: 177-184
        • Reid S.P.
        • Leung L.W.
        • Hartman A.L.
        • et al.
        Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation.
        J Virol. 2006; 80: 5156-5167
        • Ruf W.
        Emerging roles of tissue factor in viral hemorrhagic fever.
        Trends Immunol. 2004; 25: 461-464
        • Towner J.S.
        • Khristova M.L.
        • Sealy T.K.
        • et al.
        Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola.
        J Virol. 2006; 80: 6497-6516
        • Towner J.S.
        • Sealy T.K.
        • Ksiazek T.G.
        • et al.
        High-throughput molecular detection of hemorrhagic fever virus threats with applications for outbreak settings.
        J Infect Dis. 2007; 196: S205-S212
        • Centers for Disease Control and Prevention
        Interim guidance for managing patients with suspected viral hemorrhagic fever in U.S. Hospitals.
        (Available at:) (Accessed June 5, 2009)
        • Bausch D.G.
        • Towner J.S.
        • Dowell S.F.
        • et al.
        Assessment of the risk of Ebola virus transmission from bodily fluids and fomites.
        J Infect Dis. 2007; 196: S142-S147
        • Peters C.J.
        • Jahrling P.B.
        • Khan A.S.
        Patients infected with high-hazard viruses: scientific basis for infection control.
        Arch Virol Suppl. 1996; 11: 141-168
        • Francesconi P.
        • Yoti Z.
        • Declich S.
        • et al.
        Ebola hemorrhagic fever transmission and risk factors of contacts, Uganda.
        Emerg Infect Dis. 2003; 9: 1430-1437
        • Baron R.C.
        • McCormick J.B.
        • Zubeir O.A.
        Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread.
        Bull World Health Organ. 1983; 61: 997-1003
        • Kerstiens B.
        • Matthys F.
        Interventions to control virus transmission during an outbreak of Ebola hemorrhagic fever: experience from Kikwit, Democratic Republic of the Congo, 1995.
        J Infect Dis. 1999; 179: S263-S267
        • Georges A.J.
        • Leroy E.M.
        • Renaut A.A.
        • et al.
        Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: epidemiologic and health control issues.
        J Infect Dis. 1999; 179: S65-S75
        • World Health Organization
        Marburg hemmorrhagic fever in Angola-Update 26.
        (Available at:) (Accessed June 7, 2009)
        • Bausch D.G.
        • Sprecher A.G.
        • Jeffs B.
        • et al.
        Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions.
        Antiviral Res. 2008; 78: 150-161
        • Takada A.
        • Ebihara H.
        • Jones S.
        • et al.
        Protective efficacy of neutralizing antibodies against Ebola virus infection.
        Vaccine. 2007; 25: 993-999
        • Mupapa K.
        • Massamba M.
        • Kibadi K.
        • et al.
        Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee.
        J Infect Dis. 1999; 179: S18-S23
        • Jahrling P.B.
        • Geisbert J.
        • Swearengen J.R.
        • et al.
        Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses.
        Arch Virol Suppl. 1996; 11: 135-140
        • Jahrling P.B.
        • Geisbert J.B.
        • Swearengen J.R.
        • et al.
        Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates.
        J Infect Dis. 2007; 196: S400-S403
        • Oswald W.B.
        • Geisbert T.W.
        • Davis K.J.
        • et al.
        Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.
        PLoS Pathog. 2007; 3: e9
        • Huggins J.W.
        Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug.
        Rev Infect Dis. 1989; 11: S750-S761
        • Jahrling P.B.
        • Geisbert T.W.
        • Geisbert J.B.
        • et al.
        Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections.
        J Infect Dis. 1999; 179: S224-S234
        • Geisbert T.W.
        • Hensley L.E.
        • Kagan E.
        • et al.
        Postexposure protection of guinea pigs against a lethal Ebola virus challenge is conferred by RNA interference.
        J Infect Dis. 2006; 193: 1650-1657
        • Geisbert T.W.
        • Hensley L.E.
        • Jahrling P.B.
        • et al.
        Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.
        Lancet. 2003; 362: 1953-1958
        • Bray M.
        • Raymond J.L.
        • Geisbert T.
        • et al.
        3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice.
        Antiviral Res. 2002; 55: 151-159
        • Bray M.
        • Driscoll J.
        • Huggins J.W.
        Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor.
        Antiviral Res. 2000; 45: 135-147
        • Hensley L.E.
        • Stevens E.L.
        • Yan S.B.
        • et al.
        Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever.
        J Infect Dis. 2007; 196: S390-S399
        • Feldmann H.
        • Jones S.M.
        • Daddario-DiCaprio K.M.
        • et al.
        Effective post-exposure treatment of Ebola infection.
        PLoS Pathog. 2007; 3: e2
        • Reed D.S.
        • Mohamadzadeh M.
        Status and challenges of filovirus vaccines.
        Vaccine. 2007; 25: 1923-1934
        • Geisbert T.W.
        • Pushko P.
        • Anderson K.
        • et al.
        Evaluation in nonhuman primates of vaccines against Ebola virus.
        Emerg Infect Dis. 2002; 8: 503-507
        • Ignatyev G.M.
        • Agafonov A.P.
        • Streltsova M.A.
        • et al.
        Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys.
        J Biotechnol. 1996; 44: 111-118
        • Swenson D.L.
        • Warfield K.L.
        • Kuehl K.
        • et al.
        Generation of Marburg virus-like particles by co-expression of glycoprotein and matrix protein.
        FEMS Immunol Med Microbiol. 2004; 40: 27-31
        • Warfield K.L.
        • Swenson D.L.
        • Olinger G.G.
        • et al.
        Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge.
        J Infect Dis. 2007; 196: S430-S437
        • Swenson D.L.
        • Warfield K.L.
        • Negley D.L.
        • et al.
        Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections.
        Vaccine. 2005; 23: 3033-3042
        • Swenson D.L.
        • Warfield K.L.
        • Larsen T.
        • et al.
        Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses.
        Expert Rev Vaccines. 2008; 7: 417-429