Since the completion of the Human Genome Project, it has become clear that genetic
variation exists among individuals that can affect functional gene expression. This
finding raises the possibility that differences in genetic phenotypes may account
for the interindividual responses seen in the context of the alloimmune response.
This review highlights studies examining the relative role of immunologic gene polymorphism
in the context of renal and liver transplant outcomes (eg, acute rejection and graft
survival). Furthermore, it examines the limitations and pitfalls in the study designs
and concludes with the potential of single nucleotide polymorphism analysis in the
future care of transplant recipients.
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Footnotes
Sponsorship: This work is supported by a grant from the Canadian Institutes for Health Research.
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© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
