Demographic and clinical risk factors may only partially predict short- and long-term
outcomes after thoracic transplantation. The interindividual variability seen in rejection
profiles could be related to the recipient's or donor's genetic background. Rejection,
either acute or chronic, elicits an alloimmune response that involves a complex network
of cytokines, growth factors, adhesion molecules, and other molecules, which may modulate
the immune response toward rejection or, conversely, mediate graft acceptance. Herein,
the authors discuss the current evidence regarding the importance of genetic polymorphisms
as independent predictors of allograft outcome. They believe that pretransplant genotype
profiling of patients, in combination with other relevant clinical information, might
be useful to predict the risk for posttransplant adverse events and also to facilitate
the implementation of individualized immunosuppression.
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Article info
Footnotes
This work was supported by 5P50 HL 074 732-03 from the National Heart Lung and Blood Institute, National Institutes of Health.
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© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
