The role of dendritic cells (DC) in transplantation is often overshadowed by the more
prominent roles of T and B cells, which interact directly with and, in the absence
of immunosuppressive therapy, destroy the allograft. It has become increasingly recognized,
however, that these potent antigen-presenting cells exert control over the immune
response and regulate the balance between tolerance and immunity to transplanted organs
and tissues. The role that chemokines play in influencing DC function with impact
on regulation of immune responses against the graft is only beginning to be understood.
This article considers how the manipulation of DC trafficking during an alloimmune
response can affect graft outcome.
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Article info
Footnotes
The authors' work is supported by National Institute of Health grants AI60994, AI67541, and AI51698.
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
