Review Article| Volume 28, ISSUE 3, P375-384, September 2008

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Dendritic Cells and Chemokine-Directed Migration in Transplantation: Where Are We Headed?

  • Bridget L. Colvin
    Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, W1544 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA

    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
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  • Benjamin M. Matta
    Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, W1544 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA

    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
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  • Angus W. Thomson
    Corresponding author.
    Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, W1544 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA

    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Search for articles by this author
      The role of dendritic cells (DC) in transplantation is often overshadowed by the more prominent roles of T and B cells, which interact directly with and, in the absence of immunosuppressive therapy, destroy the allograft. It has become increasingly recognized, however, that these potent antigen-presenting cells exert control over the immune response and regulate the balance between tolerance and immunity to transplanted organs and tissues. The role that chemokines play in influencing DC function with impact on regulation of immune responses against the graft is only beginning to be understood. This article considers how the manipulation of DC trafficking during an alloimmune response can affect graft outcome.
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