Bioregulators are naturally occurring organic compounds that modulate many different
cellular processes within multiple organ systems. Under natural circumstances, these
substances are synthesized in minute quantities in a variety of living organisms,
and are essential for normal physiologic homeostasis. Bioregulators vary widely in
their chemical structure and are capable of regulating a wide range of physiologic
activities, such as mood, consciousness, bronchial and vascular tone, sleep, muscle
contraction, blood pressure, heart rate, temperature, and immune responses. When used
therapeutically in defined clinical circumstances, some bioregulators clearly have
beneficial pharmacologic effects, as in patients receiving hormone replacement therapy
for diabetes mellitus, hypothyroidism, or Addison's disease [
[1]
]. Bioregulators also can be administered for diagnostic purposes, such as in bronchial
provocation testing with leukotriene D4, histamine, or the nucleotide adenosine-5′-monophosphate for evaluation of airway
reactivity in asthmatic or atopic subjects [
2
,
3
].To read this article in full you will need to make a payment
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Article info
Footnotes
“The Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense (U.S. Army, U.S. Navy, U.S. Air Force), the Department of Homeland Security, or other Federal Agencies.”
This work was supported by Research Grant No. AI-55592 from the National Institutes of Health and by Exploratory Research Grant No. R074MP from the Uniformed Services University of the Health Sciences.
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