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Review Article| Volume 25, ISSUE 4, P809-825, December 2005

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Prognostic/Predictive Factors in Breast Cancer

      Systemic adjuvant chemotherapy has played a major role in improving the prognosis of patients who have breast cancer. Studies have shown that 5-year, disease-free survival benefit is being achieved with modern chemotherapy regimens. The potential value of adjuvant systemic therapy for node-negative breast cancer patients has also been confirmed in the updated overview analysis published by the Early Breast Cancer Trialists' Collaborative Group [
      Early Breast Cancer Trialists' Collaborative Group
      Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer: an overview of 61 randomized trials among 28,896 women.
      ]. Overall, recurrence-free survival and overall survival were significantly improved in the women treated with chemotherapy and tamoxifen [
      Early Breast Cancer Trialists' Collaborative Group
      Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer: an overview of 61 randomized trials among 28,896 women.
      ,
      • Bonadonna G.
      • Valagussa P.
      • Tancini G.
      • et al.
      Current status of Milan adjuvant chemotherapy trials for node-positive and node-negative breast ancer.
      ,
      • Fisher B.
      • Costantino J.
      • Redmond C.
      • et al.
      A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors.
      ,
      • Fisher B.
      • Redmond C.
      • Dimitrov N.Y.
      • et al.
      A randomized clinical trial evaluating sequential methotrexate and fluorouracil in the treatment of patients with node-negative breast cancer who have estrogen-receptor negative tumors.
      ,
      • Mansour E.G.
      • Gray R.
      • Shatila A.H.
      • et al.
      Efficiency of adjuvant chemotherapy in high-risk node negative breast cancer. An intergroup study.
      ].
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