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Review Article| Volume 25, ISSUE 2, P433-464, June 2005

A Review of Prognostic Pathologic Features and Algorithms for Patients Treated Surgically for Renal Cell Carcinoma

      It was estimated that renal cell carcinoma (RCC) would be diagnosed in 32,000 patients in the United States in 2004, with 11,200 estimated deaths [
      • Eble J.N.
      • Sauter G.
      • Epstein J.I.
      • et al.
      World Health Organization classification of tumours: pathology and genetics of tumors of the urinary system and male genital organs.
      ,
      • Jemal A.
      • Tiwari R.C.
      • Murray T.
      • et al.
      Cancer statistics 2004.
      ]. The incidence and mortality rates for RCC have risen steadily for more than 20 years among both genders; these trends are not explained by the increased use of abdominal imaging alone [
      • Chow W.H.
      • Devesa S.S.
      • Warren J.L.
      • et al.
      Rising incidence of renal cell cancer in the United States.
      ]. Prognosis for patients who have RCC is related to several pathologic features, including the TNM classification and nuclear grade, which have been incorporated into prognostic algorithms by Memorial Sloan-Kettering Cancer Center, University of California Los Angeles (UCLA), and the authors' institution.
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