Nephroblastoma, also known as Wilms tumor, is a malignant embryonal neoplasm that
is derived from nephrogenic blastemal cells, with variable recapitulation of renal
embryogenesis. Nephroblastoma has long been regarded as an illustration of the multiple-hit
theory of oncogenesis that links malformations, premalignant lesions, and neoplasia
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Footnotes
Supported in part by grant CA-023099 from the National Institutes of Health and by the American Lebanese Syrian Associated Charities (ALSAC).
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© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
