The past 3 decades have seen important changes in the study of renal tumors. The use
of traditional cytogenetics and current molecular biology techniques have helped us
to understand better the differences between the various tumor types, and have helped
to refine the histologic classification of renal neoplasia. For a long time, pathologists
have observed the range of cytoplasmic characteristics of renal tumors, including
those seen in various benign and malignant tumors. For the purpose of this article,
we have included benign and malignant neoplasms that are composed predominantly of
cells with an abundance of eosinophilic cytoplasm. The focus of this article is to
present a discussion of oncocytic renal tumors that emphasizes histopathologic, immunohistochemical,
and other ancillary techniques that are used in the routine diagnosis of the different
entities and, underscores the importance of correctly diagnosing these tumors, given
the differing prognostic implications.
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