Advertisement
Review Article| Volume 25, ISSUE 2, P247-257, June 2005

The Usefulness of Immunohistochemical Markers in the Differential Diagnosis of Renal Neoplasms

      Renal cell carcinomas (RCCs) of different histologic subtypes differ in their prognosis and therapeutic response; therefore, it is important to classify malignant epithelial tumors of the kidney correctly, as well as to differentiate them from benign ones.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Leroy X.
        • Moukassa D.
        • Copin M.C.
        • et al.
        Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma.
        Eur Urol. 2000; 37: 484-487
        • Mathers M.E.
        • Pollock A.M.
        • Marsh C.
        • et al.
        Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma.
        Histopathology. 2002; 40: 563-567
        • Wu S.L.
        • Kothari P.
        • Wheeler T.M.
        • et al.
        Cytokeratins 7 and 20 immunoreactivity in chromophobe renal cell carcinomas and renal oncocytomas.
        Mod Pathol. 2002; 15: 712-717
        • McGregor D.K.
        • Khurana K.K.
        • Cao C.
        • et al.
        Diagnosing primary and metastatic renal cell carcinoma: the use of the monoclonal antibody ‘renal cell carcinoma marker'.
        Am J Surg Pathol. 2001; 25: 1485-1492
        • Avery A.K.
        • Beckstead J.
        • Renshaw A.A.
        • et al.
        Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms.
        Am J Surg Pathol. 2000; 24: 203-210
        • Ordonez N.G.
        The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study.
        Hum Pathol. 2004; 35: 697-710
        • Kim M.K.
        • Kim S.
        Immunohistochemical profile of common epithelial neoplasms arising in the kidney.
        Appl Immunohistochem Mol Morphol. 2002; 10: 332-338
        • Dai L.
        • Lu X.H.
        • Li Z.H.
        • et al.
        Value of special stains and immunohistochemistry in the diagnosis of renal epithelial neoplasms.
        Zhonghua Bing Li Xue Za Zhi. 2004; 33: 140-142
        • Martignoni G.
        • Pea M.
        • Brunelli M.
        • et al.
        CD10 is expressed in a subset of chromophobe renal cell carcinomas.
        Mod Pathol. 2004; 17: 1455-1463
        • Yang B.
        • Ali S.Z.
        • Rosenthal D.L.
        CD10 facilitates the diagnosis of metastatic renal cell carcinoma from primary adrenal cortical neoplasm in adrenal fine-needle aspiration.
        Diagn Cytopathol. 2002; 27: 149-152
        • Gokden N.
        • Mukunyadzi P.
        • James J.D.
        • et al.
        Diagnostic utility of renal cell carcinoma marker in cytopathology.
        Appl Immunohistochem Mol Morphol. 2003; 11: 116-119
        • Langner C.
        • Wegscheider B.J.
        • Ratschek M.
        • et al.
        Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 233 tumors.
        Virchows Arch. 2004; 444: 127-134
        • Young A.N.
        • Amin M.B.
        • Moreno C.S.
        • et al.
        Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers.
        Am J Pathol. 2001; 158: 1639-1651
        • Tretiakova M.S.
        • Sahoo S.
        • Takahashi M.
        • et al.
        Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma.
        Am J Surg Pathol. 2004; 28: 69-76
        • Petit A.
        • Castillo M.
        • Santos M.
        • et al.
        KIT expression in chromophobe renal cell carcinoma: comparative immunohistochemical analysis of KIT expression in different renal cell neoplasms.
        Am J Surg Pathol. 2004; 28: 676-678
        • Pan C.C.
        • Chen P.C.
        • Chiang H.
        Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma.
        Am J Clin Pathol. 2004; 121: 878-883
        • Yamazaki K.
        • Sakamoto M.
        • Ohta T.
        • et al.
        Overexpression of KIT in chromophobe renal cell carcinoma.
        Oncogene. 2003; 22: 847-852
        • Miliaras D.
        • Karasavvidou F.
        • Papanikolaou A.
        • et al.
        KIT expression in fetal, normal adult, and neoplastic renal tissues.
        J Clin Pathol. 2004; 57: 463-466
        • Langner C.
        • Ratschek M.
        • Rehak P.
        • et al.
        Expression of MUC1 (EMA) and E-cadherin in renal cell carcinoma: a systematic immunohistochemical analysis of 188 cases.
        Mod Pathol. 2004; 17: 180-188
        • Taki A.
        • Nakatani Y.
        • Misugi K.
        • et al.
        Chromophobe renal cell carcinoma: an immunohistochemical study of 21 Japanese cases.
        Mod Pathol. 1999; 12: 310-317
        • Renshaw A.A.
        • Corless C.L.
        Papillary renal cell carcinoma. Histology and immunohistochemistry.
        Am J Surg Pathol. 1995; 19: 842-849
        • Leroy X.
        • Zini L.
        • Leteurtre E.
        • et al.
        Morphologic subtyping of papillary renal cell carcinoma: correlation with prognosis and differential expression of MUC1 between the two subtypes.
        Mod Pathol. 2002; 15: 1126-1130
        • Taylor-Papadimitriou J.
        • Burchell J.
        • Miles D.W.
        • et al.
        MUC1 and cancer.
        Biochim Biophys Acta. 1999; 1455: 301-313
        • Fleming S.
        • Symes C.E.
        The distribution of cytokeratin antigens in the kidney and in renal tumours.
        Histopathology. 1987; 11: 157-170
        • Khoury J.D.
        • Abrahams N.A.
        • Levin H.S.
        • et al.
        The utility of epithelial membrane antigen and vimentin in the diagnosis of chromophobe renal cell carcinoma.
        Ann Diagn Pathol. 2002; 6: 154-158
        • Kuroda N.
        • Toi M.
        • Yamamoto M.
        • et al.
        Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas.
        Histol Histopathol. 2004; 19: 23-28
        • Stopyra G.A.
        • Warhol M.J.
        • Multhaupt H.A.
        Cytokeratin 20 immunoreactivity in renal oncocytomas.
        J Histochem Cytochem. 2001; 49: 919-920
        • Rampino T.
        • Gregorini M.
        • Soccio G.
        • et al.
        The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma.
        Am J Surg Pathol. 2003; 27: 779-785
        • Chu P.
        • Wu E.
        • Weiss L.M.
        Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.
        Mod Pathol. 2000; 13: 962-972
        • Moll R.
        • Lowe A.
        • Laufer J.
        • et al.
        Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.
        Am J Pathol. 1992; 140: 427-447