The term “metanephric” literally refers to the permanent kidney, and hence, is not
per se, a proper specific descriptor of a renal neoplasm. Nonetheless, this term has
been applied to a series of benign neoplasms that include a purely epithelial lesion
(metanephric adenoma), a purely stromal lesion (metanephric stromal tumor), and a
mixed stromal-epithelial lesion (metanephric adenofibroma). These lesions are all
recognized in the 2004 World Health Organization renal tumor classification [
[1]
]. The nature of these neoplasms is not entirely clear, yet it seems most likely that
they are related to Wilms tumor, the most common renal neoplasm of childhood, which
commonly features variable degrees of stromal and epithelial differentiation [
[2]
]. Metanephric tumors are conceived of most readily as representing the most hyperdifferentiated,
mature form of Wilms tumor. Rare reported neoplasms have had features of malignant
Wilms tumor and benign metanephric neoplasms, and such cases may explain the rare
metanephric neoplasms that have been reported to metastasize.To read this article in full you will need to make a payment
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