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Review article| Volume 24, ISSUE 2, P531-551, June 2004

Evolution of amoxicillin/clavulanate in the treatment of adults with acute bacterial rhinosinusitis and community-acquired pneumonia in response to antimicrobial-resistance patterns

  • Thomas M File Jr.
    Correspondence
    Corresponding author. Infectious Disease Service, Akron Infectious Disease, Inc., 75 Arch Street, Suite 105, Akron, OH 44304.
    Affiliations
    Department of Internal Medicine, Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA

    Infectious Disease Service, Summa Health System, 75 Arch Street, Suite 105, Akron, OH 44304, USA
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  • Michael S Benninger
    Affiliations
    Department of Otolaryngology–Head and Neck Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
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  • Michael R Jacobs
    Affiliations
    Department of Pathology and Medicine, Case Western Reserve University, Cleveland, OH, USA

    Clinical Microbiology, University Hospitals of Cleveland, 11100 Euclid Avenue, Pathology 529, Cleveland, OH 44106, USA
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      Acute bacterial rhinosinusitis (ABRS) and community-acquired pneumonia (CAP) are common community-acquired respiratory tract infections and represent a significant burden to the health care system. Streptococcus pneumoniae and Haemophilus influenzae are two of the most common bacterial causes of ABRS and CAP [
      • Niederman M.S
      • Mandell L.A
      • Anzueto A
      • et al.
      Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention.
      ,
      • Anon J.B
      • Jacobs M.R
      • Poole M.D
      • et al.
      Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
      ]. Pneumococcal resistance to commonly used antimicrobials among S pneumoniae has increased at an alarming rate, and current antimicrobial therapies need to be tailored to combat this surge in resistance.
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