Review article| Volume 24, ISSUE 2, P329-341, June 2004

Antibiotic-resistant infections in the critically ill adult

      Infections in critically ill patients exact a high price in morbidity and mortality. Because of significant underlying disease processes and deranged physiologic status, critically ill patients are more susceptible to infection and are also more likely to have an adverse outcome from infection. Critically ill patients have multiple breaches in host defense—central venous lines, endotracheal tubes, surgical wounds, nasogastric tubes, and indwelling urinary catheters may all breach mucocutaneous barriers. A significant proportion of critically ill patients also will be immunocompromised by neutropenia, iatrogenic immunosuppression for transplantation or automimmune disease, or acquired immunodeficiency due to HIV infection.
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