Osteoporosis is a skeletal disease in which there is a loss of, or decrease in, bone
mass with a deterioration of the microarchitecture of bone tissue. The disease is
progressive, taking place over a period of years, and involves derangements in the
processes of bone turnover. These derangements can be classified as those in which
osteoclast activity (resorption) is stimulated so that more bone is removed than formed
or in which osteoblast activity (formation) is hindered such that refilling of the
resorption cavity is incomplete. Regardless of the process, a key pathologic development
is the net loss of bone mass.
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