Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is the second most common cause of death from a single infectious disease in
the world [
], with an estimated eight million new cases each year and an annual, worldwide death
toll of 2.9 million [
[2]
]. The disease may be localized, with affinity to the lungs, or disseminated, involving
multiple organs. Modern chemotherapy, appropriately prescribed and administered, cures
up to 98% of cases of previously untreated pulmonary TB when the disease is caused
by drug-susceptible tubercle bacilli [
[3]
].To read this article in full you will need to make a payment
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References
- AIDS now world's fourth biggest killer.Science. 1999; 284: 1101
- The global tuberculosis situation and the new control strategy of the World Health Organization.Tubercle. 1991; 72: 1-6
- Whither short-course chemotherapy?.Br J Dis Chest. 1981; 75: 331-357
- Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin.N Engl J Med. 1993; 328: 527-532
- The emergence of drug-resistant tuberculosis in New York City.N Engl J Med. 1993; 328: 521-526
- Drug-resistance in M. tuberculosis and other mycobacteria.Clin Chest Med. 1980; 1: 227-230
- The pattern of resistance development to rifampicin in Mycobacterium tuberculosis.Tubercle. 1972; 53: 111-117
- Isoniazid-resistance and catalase activity of tubercle bacilli. A preliminary report.Am Rev Tuberc. 1954; 69: 471-472
- The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.Nature. 1992; 358: 591-593
- Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates.J Infect Dis. 1994; 169: 1162-1165
- Catalase expression, katG, and MIC of isoniazid for Mycobacterium tuberculosis isolates from Sao Paulo, Brazil.J Infect Dis. 1995; 171: 237-240
- Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa.Antimicrob Agents Chemother. 1997; 41: 1601-1603
- Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.Mol Microbiol. 1995; 15: 235-245
- Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.J Infect Dis. 1996; 173: 196-202
- Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare.Antimicrob Agents Chemother. 1995; 39: 2276-2281
- Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City.J Infect Dis. 1993; 168: 1063-1065
- inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Science. 1994; 263: 227-230
- Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study.Lancet. 1994; 344: 293-298
- Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.J Infect Dis. 1995; 171: 240-245
- Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.Arch Pathol Lab Med. 1995; 119: 131-138
- Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.Antimicrob Agents Chemother. 1995; 39: 2472-2477
- Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level.J Clin Microbiol. 1997; 35: 719-723
- Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.Science. 1996; 272: 1641-1643
- Recombinant Mycobacterium tuberculosis KatG(S315T) is a competent catalase-peroxidase with reduced activity toward isoniazid.J Infect Dis. 1997; 176: 722-727
- Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.Science. 1998; 280: 1607-1610
- Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis.Lancet. 1993; 341: 647-650
- Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism analysis.Antimicrob Agents Chemother. 1993; 37: 2054-2058
- Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.J Clin Microbiol. 1994; 32: 1095-1098
- The rpoB gene of Mycobacterium tuberculosis.Antimicrob Agents Chemother. 1994; 38: 805-811
- Characterization of rifampin-resistance in pathogenic mycobacteria.Antimicrob Agents Chemother. 1994; 38: 2380-2386
- Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting.J Clin Microbiol. 1995; 33: 1617-1623
- Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.J Infect Dis. 1995; 171: 954-960
- Rifampicin resistance in Mycobacterium tuberculosis—rapid detection and implications in chemotherapy.S Afr Med J. 1996; 86: 50-55
- Mutations in the rpoB gene of Mycobacterium tuberculosis that interfere with PCR-single-strand conformation polymorphism analysis for rifampin susceptibility testing.J Clin Microbiol. 1997; 35: 492-494
- Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays.Genome Res. 1998; 8: 435-448
- Dideoxy fingerprinting for rapid screening of rpoB gene mutations in clinical isolates of Mycobacterium tuberculosis.J Formos Med Assoc. 1998; 97: 400-404
- Pyrazinamide susceptibility and amidase activity of tubercle bacilli.Am Rev Respir Dis. 1967; 95: 461-469
- Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.Nat Med. 1996; 2: 662-667
- Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.Antimicrob Agents Chemother. 1997; 41: 540-543
- Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms.Antimicrob Agents Chemother. 1997; 41: 636-640
- Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.Tuber Lung Dis. 1997; 78: 117-122
- pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia.Antimicrob Agents Chemother. 1999; 43: 1764-1766
- The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.Nat Med. 1997; 3: 567-570
- A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis.Antimicrob Agents Chemother. 1997; 41: 2629-2633
- Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.Antimicrob Agents Chemother. 1997; 41: 1677-1681
- A ribosomal gene mutation in streptomycin-resistant Mycobacterium tuberculosis isolates.J Infect Dis. 1993; 167: 1505-1506
- Bacterial resistance to aminoglycoside antibiotics.Trends Microbiol. 1997; 5: 234-240
- Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.Emerg Infect Dis. 1998; 4: 195-209
- Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot.Mol Microbiol. 1993; 9: 1239-1246
- The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis.Mol Microbiol. 1993; 10: 521-527
- Characterization of streptomycin resistance mechanisms among Mycobacterium tuberculosis isolates from patients in New York City.Antimicrob Agents Chemother. 1996; 40: 1186-1188
- Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities.Antimicrob Agents Chemother. 1996; 40: 1024-1026
- Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance in Mycobacterium tuberculosis.Mol Cell Probes. 1997; 11: 123-126
- Ribosomal drug resistance in mycobacteria.Res Microbiol. 1996; 147: 59-67
- Comparison of three molecular assays for rapid detection of rifampin resistance in Mycobacterium tuberculosis.J Clin Microbiol. 1998; 36: 1969-1973
- DNA sequencing with chain-terminating inhibitors.Proc Natl Acad Sci U S A. 1977; 74: 5463-5467
- Usefulness of Mycobacterium tuberculosis genomic mutations in the genes katG and inhA for the prediction of isoniazid resistance.Int J Tuberc Lung Dis. 1997; 1: 365-369
- Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.Proc Natl Acad Sci U S A. 1989; 86: 2766-2770
- Use of polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis to detect a point mutation in the catalase-peroxidase gene (katG) of Mycobacterium tuberculosis.Mol Cell Probes. 1997; 11: 59-63
- Direct genotypic detection of Mycobacterium tuberculosis rifampin resistance in clinical specimens by using single-tube heminested PCR.J Clin Microbiol. 1995; 33: 556-561
- Detection of rifampin resistance by single-strand conformation polymorphism analysis of cerebrospinal fluid of patients with tuberculosis of the central nervous system.J Clin Microbiol. 1997; 35: 2802-2806
- Detection of rifampin-resistant Mycobacterium tuberculosis in sputa by nested PCR-linked single-strand conformation polymorphism and DNA sequencing.J Clin Microbiol. 2001; 39: 2610-2617
- Evaluation of a polymerase chain reaction-based universal heteroduplex generator assay for direct detection of rifampin susceptibility of Mycobacterium tuberculosis from sputum specimens.Clin Infect Dis. 1998; 26: 446-450
- Capillary electrophoresis-based heteroduplex analysis with a universal heteroduplex generator for detection of point mutations associated with rifampin resistance in tuberculosis.Clin Chem. 2001; 47: 1195-1203
- Detection of rifampin resistance in Mycobacterium tuberculosis by use of a rapid, simple, and specific RNA/RNA mismatch assay.J Infect Dis. 1997; 176: 533-536
- Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes.Nat Biotechnol. 1999; 17: 292-296
- Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis.Antimicrob Agents Chemother. 2000; 44: 1296-1301
- Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes.Proc Natl Acad Sci U S A. 1989; 86: 6230-6234
- Rapid detection of rifampicin resistance in sputum and biopsy specimens from tuberculosis patients by PCR and line probe assay.Tuber Lung Dis. 1995; 76: 425-430
- Evaluation of the INNO-LiPA Rif.TB assay, a reverse hybridization assay for the simultaneous detection of Mycobacterium tuberculosis complex and its resistance to rifampin.Antimicrob Agents Chemother. 1997; 41: 2093-2098
- Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Greece.J Clin Microbiol. 1998; 36: 20-23
- Rapid detection of rifampin-resistant Mycobacterium tuberculosis by sequencing and line probe assay.Scand J Infect Dis. 1998; 30: 129-132
- Molecular characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Hungary by DNA sequencing and the line probe assay.J Clin Microbiol. 2001; 39: 3736-3739
- Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy.Tuber Lung Dis. 1999; 79: 343-348
- Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community.J Clin Microbiol. 2001; 39: 636-641
- Use of real-time PCR and fluorimetry for rapid detection of rifampin and isoniazid resistance-associated mutations in Mycobacterium tuberculosis.J Clin Microbiol. 2000; 38: 3194-3199
- Detection of rpoB mutations in Mycobacterium tuberculosis by biprobe analysis.J Clin Microbiol. 2001; 39: 3350-3352
- New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis.J Clin Microbiol. 2002; 40: 988-995
- Continuous fluorescence monitoring of rapid cycle DNA amplification.Biotechniques. 1997; 22: 130-139
- The LightCycler: a microvolume multisample fluorimeter with rapid temperature control.Biotechniques. 1997; 22: 176-181
- Multiplexed biochemical assays with biological chips.Nature. 1993; 364: 555-556
- Mycobacterium species identification and rifampin resistance testing with high-density DNA probe arrays.J Clin Microbiol. 1999; 37: 49-55
- Identification of rifampin-resistant Mycobacterium tuberculosis strains by hybridization, PCR, and ligase detection reaction on oligonucleotide microchips.J Clin Microbiol. 2001; 39: 2531-2540
- DNA analysis and diagnostics on oligonucleotide microchips.Proc Natl Acad Sci U S A. 1996; 93: 4913-4918
- PCR amplification on a microarray of gel-immobilized oligonucleotides: detection of bacterial toxin- and drug-resistant genes and their mutations.Biotechniques. 2000; 29: 844-857
- Solid-phase sequence scanning for drug resistance detection in tuberculosis.Mol Cell Probes. 1999; 13: 81-87
- Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance.Mol Microbiol. 1996; 22: 583-592
- Nested polymerase chain reaction for detection of Mycobacterium tuberculosis in clinical samples.J Clin Microbiol. 1993; 31: 2228-2232
- Detection of a genetic locus encoding resistance to rifampin in mycobacterial cultures and in clinical specimens.Diagn Microbiol Infect Dis. 1994; 18: 219-227
- Reliability of nucleic acid amplification for detection of Mycobacterium tuberculosis: an international collaborative quality control study among 30 laboratories.J Clin Microbiol. 1996; 34: 2522-2525
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