Preeclampsia is a disease that is unique to pregnancy and causes significant maternal,
fetal, and neonatal morbidity and mortality worldwide. No single test identifies which
women will develop preeclampsia and whether the disease will manifest early or severely.
Methods for early identification of women destined to develop preeclampsia and treatment
options other than delivery are needed urgently. A sensitive and specific screening
marker could shed light on the disease pathophysiology, identify patients who are
at risk for development of the disease, allow for targeted study of treatments among
the highest-risk groups, and define those patients who should be included in research
studies. Patients with a previous pregnancy affected by severe disease could be counseled
regarding their recurrence risk, and patients who are identified as high risk could
be followed more closely.
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Footnotes
☆This article was supported by grant HD25220-11 (L.C.G.) from the National Institute of Health.
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© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
