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Review article| Volume 23, ISSUE 2, P257-264, June 2003

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Human chorionic gonadotropin testing for early pregnancy viability and complications

      Human chorionic gonadotropin (hCG) is the principal test used for early pregnancy detection and identification of early pregnancy complications. Progesterone measurement also is useful for these purposes.
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      References

        • Cole L.A.
        Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites.
        Clin Chem. 1997; 43: 2233-2243
        • Kovalevskaya G.
        • Birken S.
        • Kakuma T.
        • O'Connor J.F.
        Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunoradiometric assay for choriocarcinoma-like hCG.
        J Endocrinol. 1999; 161: 99-106
        • Butler S.A.
        • Khanlian S.A.
        • Cole L.A.
        Detection of early pregnancy forms of human chorionic gonadotropin by home pregnancy test devices.
        Clin Chem. 2001; 47: 2131-2136
        • Elliott M.M.
        • Kardana A.
        • Lustbader J.W.
        • Cole L.A.
        Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma.
        Endocrine. 1997; 7: 15-32
        • Cole L.A.
        • Shahabi S.
        • Oz U.A.
        • Bahado-Singh R.O.
        • Mahoney M.J.
        Hyperglycosylated hCG (invasive trophoblast antigen) immunoassay: a new basis for gestational down syndrome screening.
        Clin Chem. 1999; 45: 2109-2119
        • Cole L.A.
        • Shahabi S.
        • Butler S.
        • Mitchell H.
        • Newlands E.S.
        • Behrman H.R.
        • et al.
        Utility of commonly used commercial hCG immunoassays in the diagnosis and management of trophoblastic diseases.
        Clin Chem. 2001; 47: 308-315
        • Wilcox A.J.
        • Baird D.D.
        • Dunson D.
        • McChesney R.
        • Weinberg C.R.
        Natural limits of pregnancy testing in relation to the expected menstrual period.
        JAMA. 2001; 286: 1759-1761
        • Wilcox A.J.
        • Weinberg C.R.
        • O'Connor J.F.
        • Baird D.D.
        • Schlatterer J.P.
        • Canfield R.E.
        • et al.
        Incidence of early loss of pregnancy.
        N Engl J Med. 1988; 319: 189-194
        • Wilcox A.J.
        • Weinberg C.R.
        • Wehmann R.E.
        • Armstrong E.G.
        • Canfield R.E.
        • Nisula B.C.
        Measuring early pregnancy loss: laboratory and field methods.
        Fertil Steril. 1985; 44: 366-374
      1. U.S. Food and Drug Administration, Center for Devices and Radiological Health. Guidance for over-the-counter (OTC) human chorionic gonadotropin (hCG) 510(k)s. July 22, 2000. Available at: http://www.fda.gov/cdrh/ode/guidance/1172.html. Accessed March 21, 2003.

        • Norman R.J.
        • Menabawey M.
        • Lowings C.
        • Buck R.H.
        • Chard T.
        Relationship between blood and urine concentrations of intact human chorionic gonadotropin and its free subunits in early pregnancy.
        Obstet Gynecol. 1987; 69: 590-593
        • Lehner R.
        • Kucera E.
        • Jirecek S.
        • Egarter C.
        • Husslein P.
        Ectopic pregnancy.
        Arch Gynecol Obstet. 2000; 263: 87-92
        • Tenore J.L.
        Ectopic pregnancy.
        Am Fam Physician. 2000; 61: 1080-1088
        • Lemus J.F.
        Ectopic pregnancy: an update.
        Curr Opin Obstet Gynecol. 2000; 12: 369-375
        • Lipscomb G.H.
        • Stovall T.G.
        • Ling F.W.
        Nonsurgical treatment of ectopic pregnancy.
        N Engl J Med. 2000; 343: 1325-1329
        • Ward G.
        • McKinnon L.
        • Badrick T.
        • Hickman P.E.
        Heterophilic antibodies remains a problem for the immunoassay laboratory.
        Am J Clin Pathol. 1997; 108: 417-421
        • Rotmensch S.
        • Cole L.A.
        False diagnosis and needless therapy of presumed malignant disease in women with false-positive human chorionic gonadotropin concentrations.
        Lancet. 2000; 355: 712-715
        • Vermesh M.
        • Presser S.C.
        Reproductive outcome after linear salpingostomy for ectopic gestation: a prospective 3 year follow up.
        Fertil Steril. 1992; 57: 682-684
        • Dumesic D.A.
        • Damario M.A.
        • Session D.R.
        Interstital heterotopic pregnancy in a woman conceiving by in vitro fertilization after bilateral salpingectomy.
        Mayo Clin Proc. 2001; 76: 90-92
        • Cole L.A.
        • Isozaki T.
        • Jones E.E.
        Urine β-core fragment, a potential screening test for ectopic pregnancy and spontaneous abortion.
        Fetal Diagn Ther. 1997; 12: 336-339
        • Goodwin T.M.
        • Hershman J.M.
        • Cole L.A.
        Increased concentration of the free β-subunit of human chorionic gonadotropin in hyperemesis gravidarum.
        Acta Obstet Gynecol Scand. 1994; 73: 770-772