Review article| Volume 22, ISSUE 4, P863-882, December 2002


  • Scott Harper
    Corresponding author
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA

    Epidemiology Program Office, Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
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  • Alexander Klimov
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
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  • Timothy Uyeki
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
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  • Keiji Fukuda
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Search for articles by this author
      Influenza is a highly contagious, acute, febrile respiratory illness caused by influenza A and B viruses. These viruses undergo rapid antigenic change and cause annual or near-annual seasonal epidemics of febrile respiratory disease affecting all age groups. In addition, influenza A viruses infrequently initiate explosive global epidemics of disease known as pandemics.
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