- Coffin J.M.
- Havlir D.V.
- Richman D.D.
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- HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.Science. 1995; 267: 483-489
- Viral dynamics of HIV: implications for drug development and therapeutic strategies.Ann Intern Med. 1996; 124: 984-994
- Human immunodeficiency virus type 1 drug resistance testing: a comparison of three sequence-based methods.J Clin Microbiol. 2001; 39: 2157-2165
- Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.Nat Med. 1996; 2: 753-759
- Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene.Antimicrob Agents Chemother. 1997; 41: 284-291
- Changes in human immunodeficiency virus type 1 populations after treatment interruption in patients failing antiretroviral therapy.J Virol. 2001; 75: 6410-6417
- A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs.Antimicrob Agents Chemother. 1998; 42: 269-276
- A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1.Antimicrob Agents Chemother. 2000; 44: 920-928
- A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V.Antimicrob Agents Chemother. 2000; 44: 568-573
- World-wide variation in HIV-1 phenotypic susceptibility in untreated individuals: biologically relevant values for resistance testing.AIDS. 2001; 15: 1671-1677
Lanier ER, Hellmann N, Scott J, et al. Determination of a clinically relevant “cutoff” for abacavir using the PhenoSense assay [abstract 254]. In: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Alexandria (VA): Foundation for Retrovirology and Human Health; 2001. p. 117.
- Predicting HIV-1 phenotypic resistance from genotype using a large phenotype-genotype relational database.([abstract 59])in: Abstracts of the 3rd International Workshop on HIV Drug Resistance and Treatment Strategies. International Medical Press, London1999: 41-42
- Drug resistance and predicted virologic responses to human immunodeficiency virus type 1 protease inhibitor therapy.J Infect Dis. 2000; 182: 758-765
Kempf D, Hsu A, Jiang P, et al. Response to ritonavir (RTV) intensification in indinavir (IDV) recipients is highly correlated with virtual inhibitory quotient [abstract 523]. In: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Alexandria (VA): Foundation for Retrovirology and Human Health; 2001. p. 200.
- Antiretroviral drug resistance in HIV-1.Curr Infect Dis Rep. 1999; 1: 289-297
- Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA panel.JAMA. 2000; 283: 2417-2426
- Mutations in retroviral genes associated with drug resistance: 2000–2001 update.International Antiviral News. 2000; 8: 65-91
- Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects.J Infect Dis. 1992; 165: 105-110
- An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3′-azido-3′-deoxythymidine.J Virol. 1996; 70: 8010-8018
- HIV-1 RNA serum-load and resistant viral genotypes during early zidovudine therapy.Lancet. 1995; 345: 820-824
- Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC).J Infect Dis. 1995; 171: 1411-1419
- Phenotypic and genotypic resistance patterns of HIV-1 isolates derived from individuals treated with didanosine and stavudine.AIDS. 2000; 14: F9-F15
- Emergence of zidovudine and multidrug-resistance mutations in the HIV-1 reverse transcriptase gene in therapy-naive patients receiving stavudine plus didanosine combination therapy. STADI Group.AIDS. 1999; 13: 1705-1709
- Genotypic correlates of a virologic response to stavudine after zidovudine monotherapy.J Acquir Immune Defic Syndr. 2001; 27: 377-380
- Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy. The RV43 Study Group.Antimicrob Agents Chemother. 1994; 38: 307-314
- Genotypic and phenotypic correlates of response to abacavir (ABC, 1592).([abstract 52])in: 2nd International Workshop on HIV Drug Resistance and Treatment Strategies. International Medical Press, London1998: 36
- Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.Biochemistry. 1998; 37: 15908-15917
- Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy.Antimicrob Agents Chemother. 2000; 44: 2475-2484
- L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase.Antimicrob Agents Chemother. 1995; 39: 2602-2605
- Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing NNRTI combination therapy.J Virol. 2001; 75: 4999-5008
- In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: mutations, kinetics, and frequencies.J Infect Dis. 1996; 173: 1379-1387
- Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.J Virol. 1996; 70: 8270-8276
- Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir.Antimicrob Agents Chemother. 1998; 42: 2637-2644
- HIV-1 genotypic resistance patterns predict response to saquinavir- ritonavir therapy in patients in whom previous protease inhibitor therapy had failed.Ann Intern Med. 1999; 131: 813-821
- Polymorphism of the human immunodeficiency virus type 1 (HIV-1) protease gene and response of HIV-1-infected patients to a protease inhibitor.J Clin Microbiol. 1999; 37: 2910-2912
- Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy.J Infect Dis. 2001; 184: 983-991
- Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor.Antimicrob Agents Chemother. 2001; 45: 893-900
- A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir.J Virol. 2000; 74: 4414-4419
Whitcomb J, Deeks S, Huang W, et al. Reduced susceptibility to NRTI is associated with NNRTI hypersensitivity in virus from HIV-1-infected patients [abstract 234]. In: 7th Conference on Retroviruses and Opportunistic Infections. San Francisco: Foundation for Retrovirology and Human Health; 2000. p. 120.
- Non-nucleoside reverse transcriptase inhibitor viral hypersensitivity is common and improves short-term virologic response.([abstract 87])in: Abstracts of the 4th International Workshop on HIV Drug Resistance and Treatment Strategies. International Medical Press, London2000: 69
- Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virologic response to efavirenz-based therapy.AIDS. 2001; 15: 1125-1132
- Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.Proc Natl Acad Sci USA. 1993; 90: 5653-5656
- Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase.Science. 1991; 253: 1557-1559
- 3′-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors.Antimicrob Agents Chemother. 1992; 36: 2664-2669
- Emergence of dual resistance to zidovudine and lamivudine in HIV-1-infected patients treated with zidovudine plus lamivudine as initial therapy.J Acquir Immune Defic Syndr Hum Retrovirol. 2000; 23: 26-34
- Lamivudine-resistant human immunodeficiency virus type 1 variants (184V) require multiple amino acid changes to become co-resistant to zidovudine in vivo.J Infect Dis. 1997; 176: 398-405
- A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2′,3′-dideoxy-3′-thiacytidine.J Virol. 1998; 72: 5093-5098
- Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens.JAMA. 2000; 283: 229-234
- Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: a randomized equivalence trial. CNAAB3005 International Study Team.JAMA. 2001; 285: 1155-1163
- Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine.J Infect Dis. 2000; 181: 904-911
- A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS.AIDS. 2000; 14: F83-F93
- Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial.Lancet. 1999; 353: 2195-2199
- Clinical utility of HIV-1 genotyping and expert advice: the Havana trial.AIDS. 2002; 16: 209-218
- A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy.AIDS. 2002; 16: 579-588
- Impact of treatment guided by phenotypic or genotypic resistance tests on the response to antiretroviral therapy: a randomized trial (NARVAL, ANRS 088).([abstract 85])in: Abstracts of the 4th International Workshop on HIV Drug Resistance and Treatment Strategies. International Medical Press, London2000: 67-68
- Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents, 2001.(Available at:)Accessed July 15, 2002)
- Use of genotypic resistance testing to guide HIV therapy: clinical impact and cost-effectiveness.Ann Intern Med. 2001; 134: 440-450
- Transmission and prevalence of HIV resistance among treatment-naive subjects.Antivir Ther. 2000; 5: 33-40
Hanna G, Balaguera H, Steger K, et al. Drug-selected and non-clade B pol genotypes in chronically HIV-1-infected antiretroviral-naive adults in Boston [abstract 460]. In: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Alexandria (VA): Foundation for Retrovirology and Human Health; 2001. p. 180.
Weinstock H, Zaidi I, Woods T, et al. Prevalence of mutations associated with decreased antiretroviral drug susceptibility among recently and chronically HIV-1-infected persons in 10 U.S. Cities, 1997–99 [abstract 265]. In: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Alexandria (VA): Foundation for Retrovirology and Human Health; 2001. p. 121.
☆This work is supported by Grant No. AI-01696 from the National Institutes of Health.