Dynamic Pharmacogenetic Models in Anticoagulation Therapy
This article demonstrates how a dynamic clinical-support tool can guide individualized drug therapy. We use the drug warfarin as a model to demonstrate how pharmacogenetics when combined with fundamental principles of pharmacokinetic and pharmacodynamics can provide a powerful decision-support tool to optimize personalized therapeutics.
aDepartment of Pathology and Laboratory Medicine, University of Louisville, 501 South Floyd Street, MDR-218, Louisville, KY 40202, USA
bPGXL Laboratories, 201 East Jefferson Street, Suite 309, Louisville, KY 40202, USA
Corresponding author. Department of Pathology and Laboratory Medicine, University of Louisville, 511 South Floyd Street, MDR-218, Louisville, KY 40202.
This work was supported by Grant No. K23AA014235ML and R44 HL 090055KR.
ABSTRACT